ExoCarta: Gene summary

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Gene description for AKR1C4
Gene name	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
Gene symbol	AKR1C4
Other names/aliases	AKR1C1
Species	Bos taurus
Database cross references - AKR1C4
ExoCarta	ExoCarta_282138
Vesiclepedia	VP_282138
Entrez Gene	282138
UniProt	P52898
AKR1C4 identified in sEVs derived from the following tissue/cell type
Milk	23459212

Gene ontology annotations for AKR1C4

Molecular Function
	aldose reductase (NADPH) activity	GO:0004032	IEA
	bile acid binding	GO:0032052	IEA
	androsterone dehydrogenase activity	GO:0047023	IEA
	ketosteroid monooxygenase activity	GO:0047086	IEA
Biological Process
	prostaglandin metabolic process	GO:0006693	IEA
	progesterone metabolic process	GO:0042448	IEA
	daunorubicin metabolic process	GO:0044597	IEA
	doxorubicin metabolic process	GO:0044598	IEA
Subcellular Localization
	cytosol	GO:0005829	IEA

Experiment description of studies that identified AKR1C4 in sEVs

Experiment ID

213

MISEV standards
✘	Biophysical techniques
✘	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

23459212

Organism

Bos taurus

Experiment description

"Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."

Authors

"Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."

Journal name

J Proteomics

Publication year

2013

Sample

Milk

Sample name

Staphylococcus aureus-infected-Milk

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for AKR1C4

	Protein Interactor	ExoCarta ID	Identification method	PubMed	Species
No interactions are found.

Pathways in which AKR1C4 is involved

Pathway	Evidence	Source
Arachidonate metabolism	IEA	Reactome
Bile acid and bile salt metabolism	IEA	Reactome
Drug ADME	IEA	Reactome
Fatty acid metabolism	IEA	Reactome
Metabolism	IEA	Reactome
Metabolism of fat-soluble vitamins	IEA	Reactome
Metabolism of lipids	IEA	Reactome
Metabolism of steroids	IEA	Reactome
Metabolism of vitamins and cofactors	IEA	Reactome
Prednisone ADME	IEA	Reactome
RA biosynthesis pathway	IEA	Reactome
Retinoid metabolism and transport	IEA	Reactome
Sensory Perception	IEA	Reactome
Signal Transduction	IEA	Reactome
Signaling by Nuclear Receptors	IEA	Reactome
Signaling by Retinoic Acid	IEA	Reactome
Synthesis of bile acids and bile salts	IEA	Reactome
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	IEA	Reactome
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	IEA	Reactome
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	IEA	Reactome
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	IEA	Reactome
Visual phototransduction	IEA	Reactome

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