Gene description for Atp1a1
Gene name	ATPase, Na+/K+ transporting, alpha 1 polypeptide
Gene symbol	Atp1a1
Other names/aliases	Nkaa1b
Species	Rattus norvegicus
Database cross references - Atp1a1
ExoCarta	ExoCarta_24211
Vesiclepedia	VP_24211
Entrez Gene	24211
UniProt	P06685
Atp1a1 identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041
Hepatocytes	19367702
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Atp1a1

Molecular Function     P-type sodium:potassium-exchanging transporter activity GO:0005391 IBA     P-type sodium:potassium-exchanging transporter activity GO:0005391 IDA     P-type sodium:potassium-exchanging transporter activity GO:0005391 IEA     P-type sodium:potassium-exchanging transporter activity GO:0005391 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IDA     ATP binding GO:0005524 IEA     ATP binding GO:0005524 ISO     P-type potassium transmembrane transporter activity GO:0008556 ISO     phosphatase activity GO:0016791 IEA     phosphatase activity GO:0016791 ISO     ATP hydrolysis activity GO:0016887 IEA     protein kinase binding GO:0019901 IPI     protein domain specific binding GO:0019904 IPI     ankyrin binding GO:0030506 IPI     potassium ion binding GO:0030955 IDA     potassium ion binding GO:0030955 ISO     sodium ion binding GO:0031402 IDA     sodium ion binding GO:0031402 IMP     sodium ion binding GO:0031402 ISO     ADP binding GO:0043531 IDA     phosphatidylinositol 3-kinase binding GO:0043548 IPI     transmembrane transporter binding GO:0044325 IEA     transmembrane transporter binding GO:0044325 ISO     metal ion binding GO:0046872 IEA     protein heterodimerization activity GO:0046982 IPI     protein-folding chaperone binding GO:0051087 IDA     protein-folding chaperone binding GO:0051087 IEA     protein-folding chaperone binding GO:0051087 ISO     ATPase binding GO:0051117 ISO     steroid hormone binding GO:1990239 IEA     steroid hormone binding GO:1990239 ISO Biological Process     regulation of the force of heart contraction GO:0002026 IEA     regulation of the force of heart contraction GO:0002026 ISO     regulation of sodium ion transport GO:0002028 IDA     potassium ion transport GO:0006813 IDA     sodium ion transport GO:0006814 IDA     intracellular sodium ion homeostasis GO:0006883 IBA     intracellular sodium ion homeostasis GO:0006883 IEA     intracellular sodium ion homeostasis GO:0006883 ISO     osmosensory signaling pathway GO:0007231 IEA     osmosensory signaling pathway GO:0007231 ISO     regulation of blood pressure GO:0008217 IEA     regulation of blood pressure GO:0008217 ISO     response to xenobiotic stimulus GO:0009410 IEA     response to xenobiotic stimulus GO:0009410 ISO     establishment or maintenance of transmembrane electrochemical gradient GO:0010248 IC     establishment or maintenance of transmembrane electrochemical gradient GO:0010248 IEA     energy coupled proton transmembrane transport, against electrochemical gradient GO:0015988 TAS     intracellular potassium ion homeostasis GO:0030007 IBA     intracellular potassium ion homeostasis GO:0030007 IEA     intracellular potassium ion homeostasis GO:0030007 ISO     negative regulation of glucocorticoid biosynthetic process GO:0031947 IEA     negative regulation of glucocorticoid biosynthetic process GO:0031947 ISO     sodium ion export across plasma membrane GO:0036376 IBA     sodium ion export across plasma membrane GO:0036376 IDA     sodium ion export across plasma membrane GO:0036376 IEA     sodium ion export across plasma membrane GO:0036376 ISO     negative regulation of heart contraction GO:0045822 IEA     negative regulation of heart contraction GO:0045822 ISO     positive regulation of heart contraction GO:0045823 IEA     positive regulation of heart contraction GO:0045823 ISO     positive regulation of striated muscle contraction GO:0045989 IEA     positive regulation of striated muscle contraction GO:0045989 ISO     sodium ion homeostasis GO:0055078 ISO     transmembrane transport GO:0055085 IDA     transmembrane transport GO:0055085 ISO     relaxation of cardiac muscle GO:0055119 TAS     heart contraction GO:0060047 IEA     heart contraction GO:0060047 ISO     cardiac muscle contraction GO:0060048 TAS     membrane hyperpolarization GO:0060081 IMP     cellular response to mechanical stimulus GO:0071260 IDA     cellular response to steroid hormone stimulus GO:0071383 IEA     cellular response to steroid hormone stimulus GO:0071383 ISO     regulation of cardiac muscle cell contraction GO:0086004 IMP     membrane repolarization GO:0086009 IEA     membrane repolarization GO:0086009 ISO     proton transmembrane transport GO:1902600 IBA     response to glycoside GO:1903416 IEA     response to glycoside GO:1903416 ISO     response to glycoside GO:1903416 ISO     potassium ion import across plasma membrane GO:1990573 IBA     potassium ion import across plasma membrane GO:1990573 IDA     potassium ion import across plasma membrane GO:1990573 IEA     potassium ion import across plasma membrane GO:1990573 ISO Subcellular Localization     endosome GO:0005768 IDA     endoplasmic reticulum GO:0005783 IDA     Golgi apparatus GO:0005794 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISO     sodium:potassium-exchanging ATPase complex GO:0005890 IBA     sodium:potassium-exchanging ATPase complex GO:0005890 IDA     sodium:potassium-exchanging ATPase complex GO:0005890 IEA     sodium:potassium-exchanging ATPase complex GO:0005890 ISO     caveola GO:0005901 IDA     postsynaptic density GO:0014069 IEA     postsynaptic density GO:0014069 ISO     intercalated disc GO:0014704 IDA     membrane GO:0016020 IDA     membrane GO:0016020 ISO     membrane GO:0016020 ISS     basolateral plasma membrane GO:0016323 IEA     basolateral plasma membrane GO:0016323 IMP     basolateral plasma membrane GO:0016323 ISO     apical plasma membrane GO:0016324 IEA     apical plasma membrane GO:0016324 ISO     lateral plasma membrane GO:0016328 IEA     lateral plasma membrane GO:0016328 ISO     T-tubule GO:0030315 IDA     T-tubule GO:0030315 IEA     T-tubule GO:0030315 ISO     axon GO:0030424 IEA     organelle membrane GO:0031090 IEA     organelle membrane GO:0031090 ISO     protein-containing complex GO:0032991 ISO     sperm flagellum GO:0036126 IEA     sperm flagellum GO:0036126 ISO     sarcolemma GO:0042383 IBA     sarcolemma GO:0042383 IDA     sarcolemma GO:0042383 ISO     melanosome GO:0042470 IEA