Gene description for Tgfbr2
Gene name	transforming growth factor, beta receptor II
Gene symbol	Tgfbr2
Other names/aliases	1110020H15Rik AU042018 DNIIR RIIDN TBR-II TbetaR-II TbetaRII
Species	Mus musculus
Database cross references - Tgfbr2
ExoCarta	ExoCarta_21813
Vesiclepedia	VP_21813
Entrez Gene	21813
UniProt	Q62312
Tgfbr2 identified in sEVs derived from the following tissue/cell type
Breast cancer cells	34112803
Breast cancer cells	34112803

Gene ontology annotations for Tgfbr2

Molecular Function     transmembrane receptor protein serine/threonine kinase activity GO:0004675 ISO     transforming growth factor beta receptor activity GO:0005024 IBA     transforming growth factor beta receptor activity GO:0005024 IGI     transforming growth factor beta receptor activity GO:0005024 ISO     transforming growth factor beta receptor activity, type I GO:0005025 IEA     transforming growth factor beta receptor activity, type II GO:0005026 IEA     transforming growth factor beta receptor activity, type II GO:0005026 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     glycosaminoglycan binding GO:0005539 IEA     glycosaminoglycan binding GO:0005539 ISO     activin receptor activity, type I GO:0016361 IBA     activin receptor activity, type I GO:0016361 IEA     activin receptor activity, type II GO:0016362 IEA     kinase activator activity GO:0019209 IDA     mitogen-activated protein kinase kinase kinase binding GO:0031435 ISO     type I transforming growth factor beta receptor binding GO:0034713 IBA     type I transforming growth factor beta receptor binding GO:0034713 IEA     type I transforming growth factor beta receptor binding GO:0034713 ISO     type III transforming growth factor beta receptor binding GO:0034714 ISO     SMAD binding GO:0046332 IDA     SMAD binding GO:0046332 ISO     metal ion binding GO:0046872 IEA     activin binding GO:0048185 IBA     transforming growth factor beta binding GO:0050431 IPI     transforming growth factor beta binding GO:0050431 ISO     transforming growth factor beta binding GO:0050431 ISO     molecular adaptor activity GO:0060090 ISO     transforming growth factor beta receptor activity, type III GO:0070123 IEA     BMP receptor activity GO:0098821 IEA Biological Process     branching involved in blood vessel morphogenesis GO:0001569 IMP     vasculogenesis GO:0001570 IMP     in utero embryonic development GO:0001701 IMP     epithelial to mesenchymal transition GO:0001837 IEA     epithelial to mesenchymal transition GO:0001837 ISO     heart looping GO:0001947 IMP     positive regulation of mesenchymal cell proliferation GO:0002053 IMP     lens development in camera-type eye GO:0002088 IMP     positive regulation of tolerance induction to self antigen GO:0002651 IMP     positive regulation of B cell tolerance induction GO:0002663 IMP     positive regulation of T cell tolerance induction GO:0002666 IMP     outflow tract septum morphogenesis GO:0003148 IMP     membranous septum morphogenesis GO:0003149 IMP     outflow tract morphogenesis GO:0003151 IMP     aortic valve morphogenesis GO:0003180 IEA     aortic valve morphogenesis GO:0003180 ISO     atrioventricular valve morphogenesis GO:0003181 IMP     tricuspid valve morphogenesis GO:0003186 IMP     cardiac left ventricle morphogenesis GO:0003214 IMP     endocardial cushion fusion GO:0003274 IMP     growth plate cartilage development GO:0003417 IGI     growth plate cartilage chondrocyte growth GO:0003430 IMP     protein phosphorylation GO:0006468 TAS     receptor-mediated endocytosis GO:0006898 ISO     apoptotic process GO:0006915 ISO     transforming growth factor beta receptor signaling pathway GO:0007179 IMP     transforming growth factor beta receptor signaling pathway GO:0007179 ISO     transforming growth factor beta receptor signaling pathway GO:0007179 ISS     Notch signaling pathway GO:0007219 IDA     smoothened signaling pathway GO:0007224 IMP     gastrulation GO:0007369 IMP     nervous system development GO:0007399 IBA     brain development GO:0007420 IMP     heart development GO:0007507 IBA     heart development GO:0007507 IMP     negative regulation of cell population proliferation GO:0008285 ISO     response to xenobiotic stimulus GO:0009410 IEA     response to xenobiotic stimulus GO:0009410 ISO     animal organ morphogenesis GO:0009887 ISO     regulation of gene expression GO:0010468 IMP     positive regulation of epithelial cell migration GO:0010634 IMP     positive regulation of epithelial to mesenchymal transition GO:0010718 ISO     lung development GO:0030324 IMP     BMP signaling pathway GO:0030509 IEA     activin receptor signaling pathway GO:0032924 IBA     activin receptor signaling pathway GO:0032924 IEA     embryonic hemopoiesis GO:0035162 IMP     aorta morphogenesis GO:0035909 IEA     aorta morphogenesis GO:0035909 ISO     regulation of cell population proliferation GO:0042127 IMP     positive regulation of angiogenesis GO:0045766 IGI     positive regulation of smooth muscle cell proliferation GO:0048661 ISO     embryonic cranial skeleton morphogenesis GO:0048701 IMP     artery morphogenesis GO:0048844 ISO     positive regulation of NK T cell differentiation GO:0051138 IMP     cartilage development GO:0051216 IMP     roof of mouth development GO:0060021 ISO     negative regulation of cardiac muscle cell proliferation GO:0060044 ISO     positive regulation of SMAD protein signal transduction GO:0060391 IEA     positive regulation of SMAD protein signal transduction GO:0060391 ISO     SMAD protein signal transduction GO:0060395 IDA     ventricular septum morphogenesis GO:0060412 IMP     lung morphogenesis GO:0060425 IMP     bronchus development GO:0060433 IMP     bronchus morphogenesis GO:0060434 IMP     trachea morphogenesis GO:0060439 IMP     trachea formation GO:0060440 IMP     mammary gland morphogenesis GO:0060443 IMP     lung lobe morphogenesis GO:0060463 IMP     Langerhans cell differentiation GO:0061520 IMP     secondary palate development GO:0062009 IMP     response to cholesterol GO:0070723 IDA     response to cholesterol GO:0070723 ISO     cellular response to growth factor stimulus GO:0071363 IBA     regulation of stem cell proliferation GO:0072091 IMP     positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 IMP     cell proliferation involved in endocardial cushion morphogenesis GO:1905315 IMP     superior endocardial cushion morphogenesis GO:1905316 IMP     inferior endocardial cushion morphogenesis GO:1905317 IMP     lens fiber cell apoptotic process GO:1990086 IDA     miRNA transport GO:1990428 IMP     positive regulation of reactive oxygen species metabolic process GO:2000379 IEA     positive regulation of reactive oxygen species metabolic process GO:2000379 ISO     positive regulation of CD4-positive, alpha-beta T cell proliferation GO:2000563 IEA     positive regulation of CD4-positive, alpha-beta T cell proliferation GO:2000563 ISO     regulation of stem cell differentiation GO:2000736 IEA     regulation of stem cell differentiation GO:2000736 ISO Subcellular Localization     extracellular space GO:0005615 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     plasma membrane GO:0005886 NAS     caveola GO:0005901 ISO     external side of plasma membrane GO:0009897 IDA     external side of plasma membrane GO:0009897 ISO     cell surface GO:0009986 ISO     membrane GO:0016020 ISO     receptor complex GO:0043235 ISO     membrane raft GO:0045121 ISO     membrane raft GO:0045121 ISS     activin receptor complex GO:0048179 IBA     transforming growth factor beta ligand-receptor complex GO:0070021 ISO     transforming growth factor beta ligand-receptor complex GO:0070021 ISS