Gene description for Hyou1
Gene name hypoxia up-regulated 1
Gene symbol Hyou1
Other names/aliases Cab140
Orp150
Species Rattus norvegicus
 Database cross references - Hyou1
ExoCarta ExoCarta_192235
Vesiclepedia VP_192235
Entrez Gene 192235
UniProt Q63617  
 Hyou1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Hyou1
Molecular Function
    adenyl-nucleotide exchange factor activity GO:0000774 IBA
    ATP binding GO:0005524 IEA
    ATP-dependent protein folding chaperone GO:0140662 IEA
Biological Process
    response to hypoxia GO:0001666 IDA
    response to ischemia GO:0002931 IEA
    response to ischemia GO:0002931 ISO
    response to ischemia GO:0002931 ISO
    protein folding GO:0006457 IEA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IEA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 ISO
    response to endoplasmic reticulum stress GO:0034976 IEA
    response to endoplasmic reticulum stress GO:0034976 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    cellular response to hypoxia GO:0071456 IEA
    cellular response to hypoxia GO:0071456 ISO
    negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GO:1903298 IBA
    negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GO:1903298 IDA
    negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GO:1903298 IEA
    negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway GO:1903298 ISO
    negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway GO:1903382 IEA
    negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway GO:1903382 ISO
Subcellular Localization
    mitochondrion GO:0005739 ISO
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum lumen GO:0005788 IEA
    smooth endoplasmic reticulum GO:0005790 IDA
    endoplasmic reticulum chaperone complex GO:0034663 IBA
    endoplasmic reticulum chaperone complex GO:0034663 IEA
    endoplasmic reticulum chaperone complex GO:0034663 ISO
 Experiment description of studies that identified Hyou1 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Hyou1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Pdia4 116598
Affinity Capture-Western Rattus norvegicus
2 Hspa5 25617
Affinity Capture-Western Rattus norvegicus
3 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
4 Thbs1 445442
Affinity Capture-Western Rattus norvegicus
5 Tg  
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml
 Pathways in which Hyou1 is involved
No pathways found





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