Gene description for Plp1
Gene name proteolipid protein (myelin) 1
Gene symbol Plp1
Other names/aliases DM20
Plp
jimpy
jp
msd
rsh
Species Mus musculus
 Database cross references - Plp1
ExoCarta ExoCarta_18823
Vesiclepedia VP_18823
Entrez Gene 18823
UniProt P60202  
 Plp1 identified in sEVs derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Plp1
Molecular Function
    protein binding GO:0005515 IPI
    structural constituent of myelin sheath GO:0019911 IBA
    structural constituent of myelin sheath GO:0019911 IEA
    structural constituent of myelin sheath GO:0019911 ISO
    identical protein binding GO:0042802 ISO
    protein-containing complex binding GO:0044877 IEA
    protein-containing complex binding GO:0044877 ISO
Biological Process
    inflammatory response GO:0006954 IGI
    axon ensheathment GO:0008366 IMP
    glial cell differentiation GO:0010001 ISO
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of gene expression GO:0010628 IMP
    astrocyte development GO:0014002 IGI
    central nervous system myelination GO:0022010 IBA
    central nervous system myelination GO:0022010 IMP
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    myelination GO:0042552 IGI
    myelination GO:0042552 IMP
    myelination GO:0042552 ISO
    myelination GO:0042552 TAS
    long-chain fatty acid biosynthetic process GO:0042759 IMP
    axon development GO:0061564 IBA
    axon development GO:0061564 IGI
    AMPA selective glutamate receptor signaling pathway GO:0098990 IEA
    AMPA selective glutamate receptor signaling pathway GO:0098990 ISO
    positive regulation of calcium ion transmembrane transport GO:1904427 IEA
    positive regulation of calcium ion transmembrane transport GO:1904427 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    integrin alphav-beta3 complex GO:0034683 IEA
    integrin alphav-beta3 complex GO:0034683 ISO
    myelin sheath GO:0043209 HDA
    myelin sheath GO:0043209 IBA
    myelin sheath GO:0043209 IDA
    myelin sheath GO:0043209 ISO
 Experiment description of studies that identified Plp1 in sEVs
1
Experiment ID 33
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Immunoelectron Microscopy
Western blotting
Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Plp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Cox6b1  
Co-fractionation Mus musculus
3 Lancl1  
Co-fractionation Mus musculus
4 Syp  
Co-fractionation Mus musculus
5 MAPT  
Reconstituted Complex Homo sapiens
6 Dlg4  
Affinity Capture-MS Mus musculus
7 Prnp 19122
Affinity Capture-MS Mus musculus
8 Aph1b  
Affinity Capture-MS Mus musculus
9 Aldoc 11676
Co-fractionation Mus musculus
10 Aph1a 226548
Affinity Capture-MS Mus musculus
11 Diras2  
Co-fractionation Mus musculus
12 Snap25 20614
Co-fractionation Mus musculus
13 Htt  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Plp1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here