Gene description for Cybb
Gene name	cytochrome b-245, beta polypeptide
Gene symbol	Cybb
Other names/aliases	C88302 CGD91-phox Cgd Cyd Nox2 gp91-1 gp91phox
Species	Mus musculus
Database cross references - Cybb
ExoCarta	ExoCarta_13058
Vesiclepedia	VP_13058
Entrez Gene	13058
UniProt	Q61093
Cybb identified in sEVs derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846

Gene ontology annotations for Cybb

Molecular Function     protein binding GO:0005515 IPI     electron transfer activity GO:0009055 IEA     electron transfer activity GO:0009055 ISO     superoxide-generating NAD(P)H oxidase activity GO:0016175 IDA     superoxide-generating NAD(P)H oxidase activity GO:0016175 ISO     heme binding GO:0020037 IEA     heme binding GO:0020037 ISO     voltage-gated proton channel activity GO:0030171 ISS     metal ion binding GO:0046872 IEA     protein heterodimerization activity GO:0046982 IEA     protein heterodimerization activity GO:0046982 ISO     flavin adenine dinucleotide binding GO:0050660 IEA     flavin adenine dinucleotide binding GO:0050660 ISO     superoxide-generating NADPH oxidase activity GO:0106292 ISS Biological Process     superoxide metabolic process GO:0006801 IMP     superoxide metabolic process GO:0006801 ISO     defense response GO:0006952 IBA     inflammatory response GO:0006954 IMP     response to nutrient GO:0007584 IEA     response to xenobiotic stimulus GO:0009410 IEA     response to xenobiotic stimulus GO:0009410 ISO     positive regulation of tumor necrosis factor production GO:0032760 IEA     positive regulation of tumor necrosis factor production GO:0032760 ISO     monoatomic ion transmembrane transport GO:0034220 IEA     superoxide anion generation GO:0042554 IBA     superoxide anion generation GO:0042554 IEA     superoxide anion generation GO:0042554 ISO     innate immune response GO:0045087 IMP     innate immune response GO:0045087 ISO     respiratory burst GO:0045730 IEA     respiratory burst GO:0045730 ISO     positive regulation of angiogenesis GO:0045766 IEA     positive regulation of angiogenesis GO:0045766 ISO     hydrogen peroxide biosynthetic process GO:0050665 IMP     cellular response to cadmium ion GO:0071276 IEA     cellular response to ethanol GO:0071361 IEA     hypoxia-inducible factor-1alpha signaling pathway GO:0097411 IEA     hypoxia-inducible factor-1alpha signaling pathway GO:0097411 ISO     response to aldosterone GO:1904044 IEA     cellular response to L-glutamine GO:1904845 IEA     response to angiotensin GO:1990776 IEA Subcellular Localization     nuclear envelope GO:0005635 IEA     nuclear envelope GO:0005635 ISO     cytoplasm GO:0005737 IDA     mitochondrion GO:0005739 HDA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     dendrite GO:0030425 IEA     dendrite GO:0030425 ISO     monoatomic ion channel complex GO:0034702 IEA     NADPH oxidase complex GO:0043020 IBA     NADPH oxidase complex GO:0043020 IDA     NADPH oxidase complex GO:0043020 ISO     neuronal cell body GO:0043025 IEA     neuronal cell body GO:0043025 ISO     phagocytic vesicle GO:0045335 IDA     perinuclear endoplasmic reticulum GO:0097038 IEA     perinuclear endoplasmic reticulum GO:0097038 ISO