Gene description for Hadh
Gene name hydroxyacyl-CoA dehydrogenase
Gene symbol Hadh
Other names/aliases Hadhsc
Species Rattus norvegicus
 Database cross references - Hadh
ExoCarta ExoCarta_113965
Vesiclepedia VP_113965
Entrez Gene 113965
UniProt Q9WVK7  
 Hadh identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Hadh
Molecular Function
    3-hydroxyacyl-CoA dehydrogenase activity GO:0003857 IBA
    3-hydroxyacyl-CoA dehydrogenase activity GO:0003857 IMP
    3-hydroxyacyl-CoA dehydrogenase activity GO:0003857 ISO
    3-hydroxyacyl-CoA dehydrogenase activity GO:0003857 ISS
    identical protein binding GO:0042802 ISO
    identical protein binding GO:0042802 ISS
    NAD+ binding GO:0070403 ISO
    NAD+ binding GO:0070403 ISS
Biological Process
    fatty acid beta-oxidation GO:0006635 IBA
    fatty acid beta-oxidation GO:0006635 IEA
    fatty acid beta-oxidation GO:0006635 IMP
    fatty acid beta-oxidation GO:0006635 ISO
    fatty acid beta-oxidation GO:0006635 ISS
    spermatogenesis GO:0007283 IEA
    response to xenobiotic stimulus GO:0009410 IDA
    response to hormone GO:0009725 IEP
    response to activity GO:0014823 IDA
    cell differentiation GO:0030154 IEA
    response to insulin GO:0032868 IEP
    negative regulation of insulin secretion GO:0046676 IMP
    regulation of insulin secretion GO:0050796 ISO
    regulation of insulin secretion GO:0050796 ISS
    positive regulation of cold-induced thermogenesis GO:0120162 ISO
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 ISO
    mitochondrial matrix GO:0005759 IEA
 Experiment description of studies that identified Hadh in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Hadh
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml



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