Gene description for Nme2
Gene name	NME/NM23 nucleoside diphosphate kinase 2
Gene symbol	Nme2
Other names/aliases	NDKB nm23-2 p18-12d
Species	Rattus norvegicus
Database cross references - Nme2
ExoCarta	ExoCarta_83782
Vesiclepedia	VP_83782
Entrez Gene	83782
UniProt	P19804
Nme2 identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041
Reticulocytes	21828046

Gene ontology annotations for Nme2

Molecular Function     phosphorelay sensor kinase activity GO:0000155 IEA     DNA binding GO:0003677 ISO     DNA binding GO:0003677 ISS     transcription coactivator activity GO:0003713 ISO     nucleoside diphosphate kinase activity GO:0004550 IBA     nucleoside diphosphate kinase activity GO:0004550 IDA     nucleoside diphosphate kinase activity GO:0004550 IEA     nucleoside diphosphate kinase activity GO:0004550 ISO     protein serine/threonine kinase activity GO:0004674 IDA     fatty acid binding GO:0005504 IPI     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     GDP binding GO:0019003 ISO     intermediate filament binding GO:0019215 IPI     enzyme binding GO:0019899 IPI     identical protein binding GO:0042802 IPI     identical protein binding GO:0042802 ISO     metal ion binding GO:0046872 IEA     G-quadruplex DNA binding GO:0051880 ISO     G-quadruplex DNA binding GO:0051880 ISS     heterocyclic compound binding GO:1901363 IPI Biological Process     phosphorelay signal transduction system GO:0000160 IEA     negative regulation of myeloid leukocyte differentiation GO:0002762 IDA     GTP biosynthetic process GO:0006183 IDA     GTP biosynthetic process GO:0006183 IEA     UTP biosynthetic process GO:0006228 IDA     UTP biosynthetic process GO:0006228 IEA     CTP biosynthetic process GO:0006241 IDA     CTP biosynthetic process GO:0006241 IEA     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IMP     integrin-mediated signaling pathway GO:0007229 ISO     integrin-mediated signaling pathway GO:0007229 ISS     nucleoside triphosphate biosynthetic process GO:0009142 ISO     positive regulation of neuron projection development GO:0010976 IMP     cellular response to oxidative stress GO:0034599 IEP     regulation of apoptotic process GO:0042981 IBA     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISS     positive regulation of keratinocyte differentiation GO:0045618 ISO     positive regulation of keratinocyte differentiation GO:0045618 ISS     regulation of epidermis development GO:0045682 ISO     regulation of epidermis development GO:0045682 ISS     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of DNA-templated transcription GO:0045893 ISS     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     protein autophosphorylation GO:0046777 IDA     positive regulation of epithelial cell proliferation GO:0050679 ISO     positive regulation of epithelial cell proliferation GO:0050679 ISS     response to growth hormone GO:0060416 IEP     cellular response to glucose stimulus GO:0071333 IEP     cellular response to fatty acid GO:0071398 IEP Subcellular Localization     ruffle GO:0001726 ISO     ruffle GO:0001726 ISS     nucleus GO:0005634 IEA     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     intermediate filament GO:0005882 IDA     focal adhesion GO:0005925 ISO     focal adhesion GO:0005925 ISS     lamellipodium GO:0030027 ISO     lamellipodium GO:0030027 ISS     mitochondrial membrane GO:0031966 IDA     perinuclear region of cytoplasm GO:0048471 IDA     cell periphery GO:0071944 ISO     cell periphery GO:0071944 ISS