Gene description for Gnai2
Gene name	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Gene symbol	Gnai2
Other names/aliases	Galphai2
Species	Rattus norvegicus
Database cross references - Gnai2
ExoCarta	ExoCarta_81664
Vesiclepedia	VP_81664
Entrez Gene	81664
UniProt	P04897
Gnai2 identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041
Hepatocytes	19367702
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Urine	20535238

Gene ontology annotations for Gnai2

Molecular Function     G protein-coupled receptor binding GO:0001664 IBA     GTPase activity GO:0003924 IBA     GTPase activity GO:0003924 IEA     protein binding GO:0005515 IPI     GTP binding GO:0005525 IEA     G-protein beta/gamma-subunit complex binding GO:0031683 IBA     G-protein beta/gamma-subunit complex binding GO:0031683 IEA     metal ion binding GO:0046872 IEA Biological Process     G protein-coupled adenosine receptor signaling pathway GO:0001973 IBA     G protein-coupled adenosine receptor signaling pathway GO:0001973 IDA     G protein-coupled receptor signaling pathway GO:0007186 IDA     adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 IEA     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IMP     adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 IBA     adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 ISO     G protein-coupled acetylcholine receptor signaling pathway GO:0007213 ISO     gamma-aminobutyric acid signaling pathway GO:0007214 IBA     gamma-aminobutyric acid signaling pathway GO:0007214 IDA     G protein-coupled glutamate receptor signaling pathway GO:0007216 IDA     regulation of heart contraction GO:0008016 ISO     cell population proliferation GO:0008283 ISO     positive regulation of cell population proliferation GO:0008284 IMP     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of cell migration GO:0030335 IMP     positive regulation of superoxide anion generation GO:0032930 IMP     positive regulation of NAD(P)H oxidase activity GO:0033864 IMP     positive regulation of urine volume GO:0035810 IMP     negative regulation of calcium ion-dependent exocytosis GO:0045955 IMP     modulation of chemical synaptic transmission GO:0050804 ISO     negative regulation of synaptic transmission GO:0050805 IDA     cell division GO:0051301 IEA     cell division GO:0051301 ISO     cell division GO:0051301 ISS     regulation of calcium ion transport GO:0051924 IDA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071878 IDA     positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 IMP     positive regulation of neural precursor cell proliferation GO:2000179 IMP     negative regulation of apoptotic signaling pathway GO:2001234 IMP Subcellular Localization     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     centrosome GO:0005813 IEA     centrosome GO:0005813 ISO     centrosome GO:0005813 ISS     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     heterotrimeric G-protein complex GO:0005834 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 TAS     dendrite GO:0030425 ISO     midbody GO:0030496 ISO     midbody GO:0030496 ISS     cell body GO:0044297 ISO     exocytic vesicle GO:0070382 ISO     hippocampal mossy fiber to CA3 synapse GO:0098686 ISO     neuronal dense core vesicle GO:0098992 ISO