Gene description for Fabp4
Gene name fatty acid binding protein 4, adipocyte
Gene symbol Fabp4
Other names/aliases Albp
aP2
Species Rattus norvegicus
 Database cross references - Fabp4
ExoCarta ExoCarta_79451
Vesiclepedia VP_79451
Entrez Gene 79451
 Fabp4 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Fabp4
Molecular Function
    long-chain fatty acid transmembrane transporter activity GO:0005324 ISO
    long-chain fatty acid transmembrane transporter activity GO:0005324 ISS
    fatty acid binding GO:0005504 IBA
    fatty acid binding GO:0005504 TAS
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
    long-chain fatty acid binding GO:0036041 ISO
    long-chain fatty acid binding GO:0036041 ISS
    hormone receptor binding GO:0051427 ISO
Biological Process
    negative regulation of protein kinase activity GO:0006469 ISO
    fatty acid metabolic process GO:0006631 IDA
    positive regulation of cell population proliferation GO:0008284 IMP
    response to xenobiotic stimulus GO:0009410 IEP
    response to bacterium GO:0009617 ISO
    response to gravity GO:0009629 IEP
    fatty acid transport GO:0015908 IBA
    long-chain fatty acid transport GO:0015909 ISO
    long-chain fatty acid transport GO:0015909 ISS
    cholesterol homeostasis GO:0042632 ISO
    negative regulation of DNA-templated transcription GO:0045892 ISO
    positive regulation of inflammatory response GO:0050729 ISO
    white fat cell differentiation GO:0050872 ISO
    brown fat cell differentiation GO:0050873 ISO
    response to glucocorticoid GO:0051384 IEP
    positive regulation of fat cell proliferation GO:0070346 ISO
    cellular response to lithium ion GO:0071285 ISO
    cellular response to tumor necrosis factor GO:0071356 ISO
    positive regulation of cold-induced thermogenesis GO:0120162 ISO
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    lipid droplet GO:0005811 TAS
    cytosol GO:0005829 IBA
 Experiment description of studies that identified Fabp4 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Fabp4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Amph  
Affinity Capture-Western Rattus norvegicus
2 Bin1  
Affinity Capture-Western Rattus norvegicus
3 TNK2 10188
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which Fabp4 is involved
No pathways found





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