Gene description for Pfn1
Gene name	profilin 1
Gene symbol	Pfn1
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Pfn1
ExoCarta	ExoCarta_64303
Vesiclepedia	VP_64303
Entrez Gene	64303
UniProt	P62963
Pfn1 identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Urine	20535238

Gene ontology annotations for Pfn1

Molecular Function     adenyl-nucleotide exchange factor activity GO:0000774 IEA     adenyl-nucleotide exchange factor activity GO:0000774 ISO     phosphotyrosine residue binding GO:0001784 IEA     phosphotyrosine residue binding GO:0001784 ISO     actin binding GO:0003779 IBA     actin binding GO:0003779 ISO     actin binding GO:0003779 TAS     actin monomer binding GO:0003785 IEA     actin monomer binding GO:0003785 ISO     signaling receptor binding GO:0005102 IDA     protein binding GO:0005515 IPI     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IDA     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IEA     phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISO     small GTPase binding GO:0031267 ISO     proline-rich region binding GO:0070064 IEA     proline-rich region binding GO:0070064 ISO Biological Process     neural tube closure GO:0001843 ISO     regulation of transcription by RNA polymerase II GO:0006357 ISO     actin polymerization or depolymerization GO:0008154 TAS     positive regulation of epithelial cell migration GO:0010634 IEA     positive regulation of epithelial cell migration GO:0010634 ISO     actin cytoskeleton organization GO:0030036 IEA     regulation of actin filament polymerization GO:0030833 IBA     negative regulation of actin filament polymerization GO:0030837 IEA     negative regulation of actin filament polymerization GO:0030837 ISO     positive regulation of actin filament polymerization GO:0030838 IEA     positive regulation of actin filament polymerization GO:0030838 ISO     negative regulation of actin filament bundle assembly GO:0032232 ISO     positive regulation of actin filament bundle assembly GO:0032233 IBA     positive regulation of ATP-dependent activity GO:0032781 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of viral transcription GO:0050434 IMP     modulation of chemical synaptic transmission GO:0050804 ISO     protein stabilization GO:0050821 IEA     protein stabilization GO:0050821 ISO     positive regulation of DNA metabolic process GO:0051054 IDA     positive regulation of stress fiber assembly GO:0051496 IMP     negative regulation of stress fiber assembly GO:0051497 IEA     negative regulation of stress fiber assembly GO:0051497 ISO     synapse maturation GO:0060074 ISO     cellular response to growth factor stimulus GO:0071363 IEP     modification of postsynaptic actin cytoskeleton GO:0098885 ISO     positive regulation of ruffle assembly GO:1900029 IEA     positive regulation of ruffle assembly GO:1900029 ISO     response to tetrachloromethane GO:1904772 IEP Subcellular Localization     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     cytoskeleton GO:0005856 IEA     cell cortex GO:0005938 IEA     cell cortex GO:0005938 ISO     Schaffer collateral - CA1 synapse GO:0098685 IDA     parallel fiber to Purkinje cell synapse GO:0098688 IDA     presynapse GO:0098793 IDA     postsynapse GO:0098794 IDA     glutamatergic synapse GO:0098978 ISO