Gene description for Lmna
Gene name lamin A/C
Gene symbol Lmna
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Lmna
ExoCarta ExoCarta_60374
Vesiclepedia VP_60374
Entrez Gene 60374
 Lmna identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Reticulocytes 21828046    
 Gene ontology annotations for Lmna
Molecular Function
    structural constituent of cytoskeleton GO:0005200 IBA
    protein binding GO:0005515 IPI
    protein phosphatase 1 binding GO:0008157 IPI
    identical protein binding GO:0042802 ISO
    structural constituent of nuclear lamina GO:0160123 IEA
    structural constituent of nuclear lamina GO:0160123 ISO
    structural constituent of nuclear lamina GO:0160123 ISS
Biological Process
    protein import into nucleus GO:0006606 IEA
    protein import into nucleus GO:0006606 ISO
    nucleus organization GO:0006997 ISO
    nuclear envelope organization GO:0006998 IBA
    nuclear envelope organization GO:0006998 IEA
    nuclear envelope organization GO:0006998 ISO
    nuclear envelope organization GO:0006998 ISO
    nuclear envelope organization GO:0006998 ISS
    nuclear migration GO:0007097 IBA
    spermatogenesis GO:0007283 IEP
    muscle organ development GO:0007517 ISO
    protein localization GO:0008104 ISO
    negative regulation of cell population proliferation GO:0008285 ISO
    response to mechanical stimulus GO:0009612 IEP
    positive regulation of gene expression GO:0010628 IEA
    positive regulation of gene expression GO:0010628 ISO
    regulation of cell migration GO:0030334 IEA
    regulation of cell migration GO:0030334 ISO
    establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 IEA
    establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 ISO
    heterochromatin formation GO:0031507 IBA
    regulation of protein stability GO:0031647 IEA
    regulation of protein stability GO:0031647 ISO
    regulation of telomere maintenance GO:0032204 ISO
    protein localization to nucleus GO:0034504 ISO
    protein localization to nucleus GO:0034504 ISO
    protein localization to nucleus GO:0034504 ISS
    positive regulation of osteoblast differentiation GO:0045669 IMP
    nuclear pore localization GO:0051664 IBA
    ventricular cardiac muscle cell development GO:0055015 IEA
    ventricular cardiac muscle cell development GO:0055015 ISO
    cellular response to hypoxia GO:0071456 IEA
    cellular response to hypoxia GO:0071456 ISO
    negative regulation of mesenchymal cell proliferation GO:0072201 IEA
    negative regulation of mesenchymal cell proliferation GO:0072201 ISO
    negative regulation of release of cytochrome c from mitochondria GO:0090201 IEA
    negative regulation of release of cytochrome c from mitochondria GO:0090201 ISO
    cellular senescence GO:0090398 IEA
    cellular senescence GO:0090398 IEP
    cellular senescence GO:0090398 ISO
    cellular senescence GO:0090398 ISS
    protein localization to nuclear envelope GO:0090435 IBA
    regulation of protein localization to nucleus GO:1900180 IEA
    regulation of protein localization to nucleus GO:1900180 ISO
    negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243 IEA
    negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243 ISO
    negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243 ISS
    negative regulation of adipose tissue development GO:1904178 IMP
    DNA double-strand break attachment to nuclear envelope GO:1990683 IEA
    DNA double-strand break attachment to nuclear envelope GO:1990683 ISO
    DNA double-strand break attachment to nuclear envelope GO:1990683 ISS
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IEA
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nuclear envelope GO:0005635 IBA
    nuclear envelope GO:0005635 IDA
    nuclear envelope GO:0005635 IEA
    nuclear envelope GO:0005635 ISO
    nuclear envelope GO:0005635 ISS
    lamin filament GO:0005638 IEA
    lamin filament GO:0005638 ISO
    nuclear lamina GO:0005652 IBA
    nuclear lamina GO:0005652 IEA
    nuclear lamina GO:0005652 ISO
    nuclear lamina GO:0005652 ISS
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 ISS
    intermediate filament GO:0005882 IEA
    nuclear matrix GO:0016363 IDA
    nuclear matrix GO:0016363 IEA
    nuclear matrix GO:0016363 ISO
    nuclear speck GO:0016607 IEA
    nuclear speck GO:0016607 ISO
    nuclear membrane GO:0031965 IEA
    nuclear membrane GO:0031965 ISO
    site of double-strand break GO:0035861 IEA
    site of double-strand break GO:0035861 ISO
    site of double-strand break GO:0035861 ISS
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Lmna in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
3
Experiment ID 96
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Lmna
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sumo3  
Affinity Capture-MS Rattus norvegicus
2 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Lmna is involved
No pathways found





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