Gene description for NEFL
Gene name	neurofilament, light polypeptide
Gene symbol	NEFL
Other names/aliases	CMT1F CMT2E NF-L NF68 NFL PPP1R110
Species	Homo sapiens
Database cross references - NEFL
ExoCarta	ExoCarta_4747
Vesiclepedia	VP_4747
Entrez Gene	4747
HGNC	7739
MIM	162280
UniProt	P07196
NEFL identified in sEVs derived from the following tissue/cell type
Liver cancer cells	25265333

Gene ontology annotations for NEFL

Molecular Function     structural constituent of cytoskeleton GO:0005200 IDA     protein binding GO:0005515 IPI     protein domain specific binding GO:0019904 IEA     protein-macromolecule adaptor activity GO:0030674 ISS     identical protein binding GO:0042802 IPI     phospholipase binding GO:0043274 IEA     protein-containing complex binding GO:0044877 IEA     structural constituent of postsynaptic intermediate filament cytoskeleton GO:0099184 IBA Biological Process     microtubule cytoskeleton organization GO:0000226 IEA     axonogenesis GO:0007409 IEA     anterograde axonal transport GO:0008089 IMP     retrograde axonal transport GO:0008090 IMP     response to toxic substance GO:0009636 IEA     peripheral nervous system axon regeneration GO:0014012 IEA     axonal transport of mitochondrion GO:0019896 IMP     spinal cord development GO:0021510 IEA     hippocampus development GO:0021766 IEA     cerebral cortex development GO:0021987 IEA     regulation of axon diameter GO:0031133 IEA     neurofilament bundle assembly GO:0033693 IBA     neurofilament bundle assembly GO:0033693 IDA     neurofilament bundle assembly GO:0033693 IMP     locomotion GO:0040011 IEA     response to peptide hormone GO:0043434 IEA     intermediate filament polymerization or depolymerization GO:0045105 IEA     intermediate filament organization GO:0045109 IMP     positive regulation of axonogenesis GO:0050772 IEA     neuromuscular process controlling balance GO:0050885 IEA     protein polymerization GO:0051258 IEA     response to corticosterone GO:0051412 IEA     neurofilament cytoskeleton organization GO:0060052 IEA     regulation of synapse maturation GO:0090128 IEA     motor neuron apoptotic process GO:0097049 IEA     postsynaptic modulation of chemical synaptic transmission GO:0099170 IEA     postsynaptic intermediate filament cytoskeleton organization GO:0099185 IEA     response to sodium arsenite GO:1903935 IEA     response to acrylamide GO:1903937 IEA     negative regulation of motor neuron apoptotic process GO:2000672 IEA Subcellular Localization     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISS     cytosol GO:0005829 TAS     intermediate filament GO:0005882 IBA     neurofilament GO:0005883 IDA     axon GO:0030424 IBA     axon GO:0030424 IDA     growth cone GO:0030426 IEA     neuromuscular junction GO:0031594 IEA     Schaffer collateral - CA1 synapse GO:0098685 IEA     cholinergic synapse GO:0098981 IEA     postsynaptic intermediate filament cytoskeleton GO:0099160 IBA     presynaptic intermediate filament cytoskeleton GO:0099182 IEA     axon cytoplasm GO:1904115 IEA