Gene description for Nostrin
Gene name nitric oxide synthase trafficker
Gene symbol Nostrin
Other names/aliases Daip2
mDaIP2
Species Mus musculus
 Database cross references - Nostrin
ExoCarta ExoCarta_329416
Vesiclepedia VP_329416
Entrez Gene 329416
UniProt Q6WKZ7  
 Nostrin identified in sEVs derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Nostrin
Molecular Function
    DNA binding GO:0003677 IDA
    protein binding GO:0005515 IPI
Biological Process
    endocytosis GO:0006897 IEA
    signal transduction GO:0007165 IEA
    negative regulation of DNA-templated transcription GO:0045892 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IEA
    cytoplasmic vesicle GO:0031410 IEA
 Experiment description of studies that identified Nostrin in sEVs
1
Experiment ID 214
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Nostrin
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ocln  
Co-fractionation Mus musculus
2 Sos1  
Co-fractionation Mus musculus
3 Dab2 13132
Co-fractionation Mus musculus
4 Prss8  
Co-fractionation Mus musculus
View the network image/svg+xml



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