Gene description for Sptbn1
Gene name spectrin, beta, non-erythrocytic 1
Gene symbol Sptbn1
Other names/aliases Spnb1
Spnb2
Species Rattus norvegicus
 Database cross references - Sptbn1
ExoCarta ExoCarta_305614
Vesiclepedia VP_305614
Entrez Gene 305614
 Sptbn1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Sptbn1
Molecular Function
    structural constituent of cytoskeleton GO:0005200 ISO
    phospholipid binding GO:0005543 IEA
    ankyrin binding GO:0030506 ISO
    protein-containing complex binding GO:0044877 IPI
    actin filament binding GO:0051015 IBA
    GTPase binding GO:0051020 ISO
Biological Process
    mitotic cytokinesis GO:0000281 ISO
    plasma membrane organization GO:0007009 ISO
    central nervous system development GO:0007417 ISO
    central nervous system formation GO:0021556 ISO
    actin cytoskeleton organization GO:0030036 IBA
    actin cytoskeleton organization GO:0030036 ISO
    positive regulation of interleukin-2 production GO:0032743 ISO
    Golgi to plasma membrane protein transport GO:0043001 ISO
    actin filament capping GO:0051693 IEA
    regulation of SMAD protein signal transduction GO:0060390 ISO
    membrane assembly GO:0071709 ISO
    protein localization to plasma membrane GO:0072659 IBA
    protein localization to plasma membrane GO:0072659 ISO
    regulation of protein localization to plasma membrane GO:1903076 ISO
    positive regulation of protein localization to plasma membrane GO:1903078 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    spectrin GO:0008091 IEA
    postsynaptic density GO:0014069 ISO
    membrane GO:0016020 ISO
    cell junction GO:0030054 IBA
    axolemma GO:0030673 ISO
    cortical cytoskeleton GO:0030863 ISO
    cortical actin cytoskeleton GO:0030864 IBA
    M band GO:0031430 ISO
    cuticular plate GO:0032437 ISO
    protein-containing complex GO:0032991 IDA
    cell projection GO:0042995 IBA
    postsynapse GO:0098794 IDA
    glutamatergic synapse GO:0098978 IDA
 Experiment description of studies that identified Sptbn1 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Sptbn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Epb41l2  
Affinity Capture-Western Rattus norvegicus
2 Epb4.1  
Affinity Capture-Western Rattus norvegicus
3 Actn1 81634
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml
 Pathways in which Sptbn1 is involved
No pathways found





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