Gene description for Nedd4l
Gene name neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Gene symbol Nedd4l
Other names/aliases Nedd4-2
Species Rattus norvegicus
 Database cross references - Nedd4l
ExoCarta ExoCarta_291553
Vesiclepedia VP_291553
Entrez Gene 291553
 Nedd4l identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Nedd4l
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    potassium channel regulator activity GO:0015459 ISO
    sodium channel regulator activity GO:0017080 ISO
    potassium channel inhibitor activity GO:0019870 IMP
    potassium channel inhibitor activity GO:0019870 ISO
    sodium channel inhibitor activity GO:0019871 IBA
    sodium channel inhibitor activity GO:0019871 ISO
    transmembrane transporter binding GO:0044325 ISO
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 ISO
Biological Process
    regulation of sodium ion transport GO:0002028 ISO
    negative regulation of systemic arterial blood pressure GO:0003085 ISO
    regulation of membrane depolarization GO:0003254 ISO
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 ISO
    protein monoubiquitination GO:0006513 IMP
    sodium ion transport GO:0006814 ISO
    response to salt stress GO:0009651 ISO
    positive regulation of sodium ion transport GO:0010765 ISO
    negative regulation of sodium ion transport GO:0010766 ISO
    protein ubiquitination GO:0016567 ISO
    regulation of protein stability GO:0031647 ISO
    regulation of monoatomic ion transmembrane transport GO:0034765 ISO
    regulation of membrane potential GO:0042391 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    positive regulation of protein catabolic process GO:0045732 IMP
    regulation of dendrite morphogenesis GO:0048814 IBA
    establishment of localization in cell GO:0051649 ISO
    regulation of membrane repolarization GO:0060306 ISO
    protein K48-linked ubiquitination GO:0070936 ISO
    ventricular cardiac muscle cell action potential GO:0086005 IMP
    regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 ISO
    regulation protein catabolic process at postsynapse GO:0140252 ISO
    regulation of potassium ion transmembrane transporter activity GO:1901016 ISO
    negative regulation of potassium ion transmembrane transporter activity GO:1901017 IMP
    negative regulation of potassium ion transmembrane transporter activity GO:1901017 ISO
    negative regulation of potassium ion transmembrane transport GO:1901380 ISO
    regulation of sodium ion transmembrane transport GO:1902305 ISO
    negative regulation of sodium ion transmembrane transport GO:1902306 ISO
    negative regulation of sodium ion import across plasma membrane GO:1903783 ISO
    positive regulation of dendrite extension GO:1903861 ISO
    negative regulation of protein localization to cell surface GO:2000009 ISO
    negative regulation of sodium ion transmembrane transporter activity GO:2000650 ISO
    regulation of bicellular tight junction assembly GO:2000810 ISO
    positive regulation of cation channel activity GO:2001259 ISO
    positive regulation of caveolin-mediated endocytosis GO:2001288 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    plasma membrane GO:0005886 ISO
    apical plasma membrane GO:0016324 ISO
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Nedd4l in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Nedd4l
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNK2 10188
Reconstituted Complex Homo sapiens
2 Hcn1  
Affinity Capture-Western Rattus norvegicus
3 APBB1  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 Slc22a8  
Affinity Capture-Western Rattus norvegicus
View the network image/svg+xml
 Pathways in which Nedd4l is involved
No pathways found





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