Gene description for PLCB1
Gene name phospholipase C, beta 1 (phosphoinositide-specific)
Gene symbol PLCB1
Other names/aliases -
Species Bos taurus
 Database cross references - PLCB1
ExoCarta ExoCarta_287026
Vesiclepedia VP_287026
Entrez Gene 287026
UniProt P10894  
 PLCB1 identified in sEVs derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for PLCB1
Molecular Function
    phosphatidylinositol phospholipase C activity GO:0004435 IEA
    calcium ion binding GO:0005509 IEA
    calmodulin binding GO:0005516 IEA
Biological Process
    memory GO:0007613 IEA
    lipid catabolic process GO:0016042 IEA
    phosphatidylinositol-mediated signaling GO:0048015 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nuclear speck GO:0016607 IEA
 Experiment description of studies that identified PLCB1 in sEVs
1
Experiment ID 213
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description "Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."
Authors "Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PLCB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EGFR 1956
Biochemical Activity Homo sapiens
2 SLC9A3R1 9368
Reconstituted Complex Homo sapiens
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