Gene description for COX2
Gene name cytochrome c oxidase II, mitochondrial
Gene symbol COX2
Other names/aliases COII
Species Rattus norvegicus
 Database cross references - COX2
ExoCarta ExoCarta_26198
Vesiclepedia VP_26198
Entrez Gene 26198
UniProt P00406  
 COX2 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for COX2
Molecular Function
    cytochrome-c oxidase activity GO:0004129 IBA
    cytochrome-c oxidase activity GO:0004129 ISO
    cytochrome-c oxidase activity GO:0004129 ISS
    copper ion binding GO:0005507 IEA
Biological Process
    response to hypoxia GO:0001666 IEP
    lactation GO:0007595 IEP
    ATP synthesis coupled electron transport GO:0042773 IBA
    positive regulation of vasoconstriction GO:0045907 ISO
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 ISO
    mitochondrial membrane GO:0031966 ISO
    respiratory chain complex IV GO:0045277 ISO
    respiratory chain complex IV GO:0045277 ISS
 Experiment description of studies that identified COX2 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for COX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sumo3  
Affinity Capture-MS Rattus norvegicus
2 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml



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