Gene description for Prkaca
Gene name protein kinase, cAMP-dependent, catalytic, alpha
Gene symbol Prkaca
Other names/aliases Cs-PKA
PKCA1
Species Rattus norvegicus
 Database cross references - Prkaca
ExoCarta ExoCarta_25636
Vesiclepedia VP_25636
Entrez Gene 25636
 Prkaca identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Prkaca
Molecular Function
    magnesium ion binding GO:0000287 IEA
    magnesium ion binding GO:0000287 ISO
    protein kinase activity GO:0004672 ISO
    protein serine/threonine kinase activity GO:0004674 ISO
    protein serine/threonine kinase activity GO:0004674 TAS
    cAMP-dependent protein kinase activity GO:0004691 IBA
    cAMP-dependent protein kinase activity GO:0004691 IDA
    cAMP-dependent protein kinase activity GO:0004691 IEA
    cAMP-dependent protein kinase activity GO:0004691 IMP
    cAMP-dependent protein kinase activity GO:0004691 ISO
    cAMP-dependent protein kinase activity GO:0004691 TAS
    protein serine/threonine/tyrosine kinase activity GO:0004712 IEA
    protein serine/threonine/tyrosine kinase activity GO:0004712 ISO
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP binding GO:0005524 ISO
    protein kinase binding GO:0019901 IEA
    protein kinase binding GO:0019901 IPI
    protein kinase binding GO:0019901 ISO
    protein domain specific binding GO:0019904 IEA
    protein domain specific binding GO:0019904 ISO
    manganese ion binding GO:0030145 IEA
    manganese ion binding GO:0030145 ISO
    small GTPase binding GO:0031267 IPI
    ubiquitin protein ligase binding GO:0031625 IEA
    ubiquitin protein ligase binding GO:0031625 ISO
    protein kinase A regulatory subunit binding GO:0034237 IBA
    protein kinase A regulatory subunit binding GO:0034237 IC
    protein kinase A regulatory subunit binding GO:0034237 IEA
    protein kinase A regulatory subunit binding GO:0034237 ISO
    protein-containing complex binding GO:0044877 IPI
    protein serine kinase activity GO:0106310 IEA
    protein serine kinase activity GO:0106310 ISO
Biological Process
    mesoderm formation GO:0001707 IEA
    mesoderm formation GO:0001707 ISO
    neural tube closure GO:0001843 IEA
    neural tube closure GO:0001843 ISO
    mRNA processing GO:0006397 IEA
    mRNA processing GO:0006397 ISO
    protein phosphorylation GO:0006468 IDA
    protein phosphorylation GO:0006468 ISO
    protein phosphorylation GO:0006468 ISO
    protein export from nucleus GO:0006611 IEA
    protein export from nucleus GO:0006611 ISO
    protein export from nucleus GO:0006611 ISO
    signal transduction GO:0007165 IBA
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IEA
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 ISO
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 IEA
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 ISO
    positive regulation of cell population proliferation GO:0008284 IMP
    peptidyl-serine phosphorylation GO:0018105 IDA
    peptidyl-serine phosphorylation GO:0018105 IMP
    peptidyl-serine phosphorylation GO:0018105 ISO
    peptidyl-serine phosphorylation GO:0018105 ISO
    peptidyl-threonine phosphorylation GO:0018107 ISO
    positive regulation of insulin secretion GO:0032024 IEA
    positive regulation of insulin secretion GO:0032024 ISO
    cellular response to heat GO:0034605 IEA
    cellular response to heat GO:0034605 ISO
    cellular response to heat GO:0034605 ISS
    regulation of cellular respiration GO:0043457 IDA
    positive regulation of cholesterol biosynthetic process GO:0045542 IEA
    positive regulation of cholesterol biosynthetic process GO:0045542 ISO
    regulation of osteoblast differentiation GO:0045667 IEA
    regulation of osteoblast differentiation GO:0045667 ISO
    positive regulation of gluconeogenesis GO:0045722 IEA
    positive regulation of gluconeogenesis GO:0045722 ISO
    negative regulation of smoothened signaling pathway GO:0045879 IEA
    negative regulation of smoothened signaling pathway GO:0045879 ISO
    protein autophosphorylation GO:0046777 ISO
    positive regulation of protein export from nucleus GO:0046827 IEA
    positive regulation of protein export from nucleus GO:0046827 ISO
    sperm capacitation GO:0048240 IEA
    sperm capacitation GO:0048240 ISO
    spontaneous exocytosis of neurotransmitter GO:0048792 IMP
    modulation of chemical synaptic transmission GO:0050804 ISO
    negative regulation of meiotic cell cycle GO:0051447 IDA
    regulation of cell cycle GO:0051726 IEA
    regulation of cell cycle GO:0051726 ISO
    regulation of synaptic transmission, glutamatergic GO:0051966 IDA
    regulation of proteasomal protein catabolic process GO:0061136 IEA
    regulation of proteasomal protein catabolic process GO:0061136 ISO
    cellular response to cold GO:0070417 IEA
    cellular response to cold GO:0070417 ISO
    regulation of protein processing GO:0070613 IEA
    regulation of protein processing GO:0070613 ISO
    cellular response to glucose stimulus GO:0071333 IEA
    cellular response to glucose stimulus GO:0071333 ISO
    cellular response to parathyroid hormone stimulus GO:0071374 IEA
    cellular response to parathyroid hormone stimulus GO:0071374 ISO
    cellular response to glucagon stimulus GO:0071377 IEA
    cellular response to glucagon stimulus GO:0071377 ISO
    postsynaptic modulation of chemical synaptic transmission GO:0099170 IEA
    postsynaptic modulation of chemical synaptic transmission GO:0099170 ISO
    cAMP/PKA signal transduction GO:0141156 ISO
    negative regulation of meiotic cell cycle process involved in oocyte maturation GO:1904145 ISO
    negative regulation of TORC1 signaling GO:1904262 IEA
    negative regulation of TORC1 signaling GO:1904262 ISO
    negative regulation of TORC1 signaling GO:1904262 ISS
    negative regulation of glycolytic process through fructose-6-phosphate GO:1904539 IEA
    negative regulation of glycolytic process through fructose-6-phosphate GO:1904539 ISO
    protein localization to lipid droplet GO:1990044 IEA
    protein localization to lipid droplet GO:1990044 ISO
    regulation of bicellular tight junction assembly GO:2000810 IEA
    regulation of bicellular tight junction assembly GO:2000810 ISO
Subcellular Localization
    acrosomal vesicle GO:0001669 IEA
    acrosomal vesicle GO:0001669 ISO
    acrosomal vesicle GO:0001669 ISS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
    centrosome GO:0005813 IEA
    centrosome GO:0005813 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    axoneme GO:0005930 IEA
    axoneme GO:0005930 ISO
    cAMP-dependent protein kinase complex GO:0005952 IBA
    cAMP-dependent protein kinase complex GO:0005952 IDA
    cAMP-dependent protein kinase complex GO:0005952 IEA
    cAMP-dependent protein kinase complex GO:0005952 ISO
    nuclear speck GO:0016607 IEA
    nuclear speck GO:0016607 ISO
    nucleotide-activated protein kinase complex GO:0031588 ISO
    neuromuscular junction GO:0031594 IDA
    neuromuscular junction GO:0031594 IEA
    neuromuscular junction GO:0031594 ISO
    protein-containing complex GO:0032991 IDA
    sperm flagellum GO:0036126 IEA
    sperm flagellum GO:0036126 ISO
    sperm flagellum GO:0036126 ISS
    germinal vesicle GO:0042585 ISO
    plasma membrane raft GO:0044853 IEA
    plasma membrane raft GO:0044853 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
    sperm midpiece GO:0097225 ISO
    sperm midpiece GO:0097225 ISS
    ciliary base GO:0097546 IEA
    ciliary base GO:0097546 ISO
    presynapse GO:0098793 IDA
    presynapse GO:0098793 IMP
    postsynapse GO:0098794 IDA
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IEA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Prkaca in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Prkaca
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST2H2BE 8349
Biochemical Activity Homo sapiens
2 Dact1  
Affinity Capture-Western Rattus norvegicus
3 Id2  
Biochemical Activity Rattus norvegicus
4 Dact2  
Affinity Capture-Western Rattus norvegicus
5 HIST1H4A 8359
Biochemical Activity Homo sapiens
6 Id1  
Biochemical Activity Rattus norvegicus
7 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
8 MBP 4155
Biochemical Activity Homo sapiens
9 Dact3  
Affinity Capture-Western Rattus norvegicus
10 Mef2d  
Two-hybrid Rattus norvegicus
View the network image/svg+xml
 Pathways in which Prkaca is involved
No pathways found





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