Gene description for Rab3a
Gene name RAB3A, member RAS oncogene family
Gene symbol Rab3a
Other names/aliases RAB3
Species Rattus norvegicus
 Database cross references - Rab3a
ExoCarta ExoCarta_25531
Vesiclepedia VP_25531
Entrez Gene 25531
UniProt P63012  
 Rab3a identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Rab3a
Molecular Function
    ATPase activator activity GO:0001671 IDA
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IEA
    GTPase activity GO:0003924 ISO
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IDA
    GTP binding GO:0005525 IEA
    protein-macromolecule adaptor activity GO:0030674 IEA
    protein-macromolecule adaptor activity GO:0030674 ISO
    GTP-dependent protein binding GO:0030742 IEA
    GTP-dependent protein binding GO:0030742 ISO
    myosin V binding GO:0031489 IBA
    myosin V binding GO:0031489 IEA
    myosin V binding GO:0031489 ISO
    GDP-dissociation inhibitor binding GO:0051021 IPI
    ATPase binding GO:0051117 IPI
Biological Process
    plasma membrane repair GO:0001778 IEA
    plasma membrane repair GO:0001778 ISO
    respiratory system process GO:0003016 IEA
    respiratory system process GO:0003016 ISO
    intracellular protein transport GO:0006886 IEA
    exocytosis GO:0006887 ISO
    mitochondrion organization GO:0007005 IEA
    mitochondrion organization GO:0007005 ISO
    neuromuscular synaptic transmission GO:0007274 IEA
    neuromuscular synaptic transmission GO:0007274 ISO
    axonogenesis GO:0007409 IBA
    axonogenesis GO:0007409 IEA
    axonogenesis GO:0007409 ISO
    post-embryonic development GO:0009791 IEA
    post-embryonic development GO:0009791 ISO
    regulation of synaptic vesicle priming GO:0010807 IDA
    regulation of dopamine secretion GO:0014059 IDA
    synaptic vesicle exocytosis GO:0016079 IBA
    synaptic vesicle exocytosis GO:0016079 IEA
    synaptic vesicle exocytosis GO:0016079 IMP
    synaptic vesicle exocytosis GO:0016079 ISO
    synaptic vesicle maturation GO:0016188 IEA
    synaptic vesicle maturation GO:0016188 ISO
    calcium-ion regulated exocytosis GO:0017156 ISO
    regulation of exocytosis GO:0017157 ISO
    insulin secretion GO:0030073 IEA
    insulin secretion GO:0030073 ISO
    lung development GO:0030324 IEA
    lung development GO:0030324 ISO
    regulation of synaptic vesicle fusion to presynaptic active zone membrane GO:0031630 IEA
    regulation of synaptic vesicle fusion to presynaptic active zone membrane GO:0031630 ISO
    regulation of synaptic vesicle fusion to presynaptic active zone membrane GO:0031630 ISO
    regulation of synaptic vesicle fusion to presynaptic active zone membrane GO:0031630 ISS
    lysosome localization GO:0032418 IEA
    lysosome localization GO:0032418 ISO
    Rab protein signal transduction GO:0032482 IC
    synaptic vesicle recycling GO:0036465 IMP
    regulated exocytosis GO:0045055 ISO
    regulation of short-term neuronal synaptic plasticity GO:0048172 IEA
    regulation of short-term neuronal synaptic plasticity GO:0048172 ISO
    regulation of short-term neuronal synaptic plasticity GO:0048172 ISS
    synaptic vesicle transport GO:0048489 IEA
    synaptic vesicle transport GO:0048489 ISO
    maintenance of presynaptic active zone structure GO:0048790 IEA
    maintenance of presynaptic active zone structure GO:0048790 ISO
    sensory perception of touch GO:0050975 IEA
    sensory perception of touch GO:0050975 ISO
    response to electrical stimulus GO:0051602 IEA
    response to electrical stimulus GO:0051602 ISO
    establishment of localization in cell GO:0051649 ISO
    acrosomal vesicle exocytosis GO:0060478 IBA
    acrosomal vesicle exocytosis GO:0060478 IEA
    acrosomal vesicle exocytosis GO:0060478 ISO
    evoked neurotransmitter secretion GO:0061670 IEA
    evoked neurotransmitter secretion GO:0061670 ISO
    synaptic vesicle clustering GO:0097091 IEA
    synaptic vesicle clustering GO:0097091 ISO
    regulation of presynaptic dense core granule exocytosis GO:0099161 IEA
    regulation of presynaptic dense core granule exocytosis GO:0099161 ISO
    positive regulation of regulated secretory pathway GO:1903307 IEA
    positive regulation of regulated secretory pathway GO:1903307 ISO
    regulation of plasma membrane repair GO:1905684 IEA
    regulation of plasma membrane repair GO:1905684 ISO
    regulation of synaptic vesicle exocytosis GO:2000300 IDA
Subcellular Localization
    acrosomal vesicle GO:0001669 IEA
    acrosomal vesicle GO:0001669 ISO
    lysosome GO:0005764 IEA
    endosome GO:0005768 IBA
    endosome GO:0005768 IEA
    endosome GO:0005768 ISO
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    synaptic vesicle GO:0008021 IBA
    synaptic vesicle GO:0008021 IDA
    synaptic vesicle GO:0008021 ISO
    secretory granule GO:0030141 IDA
    axon GO:0030424 IBA
    axon GO:0030424 IDA
    synaptic vesicle membrane GO:0030672 EXP
    synaptic vesicle membrane GO:0030672 IBA
    synaptic vesicle membrane GO:0030672 IDA
    synaptic vesicle membrane GO:0030672 IDA
    synaptic vesicle membrane GO:0030672 IEA
    synaptic vesicle membrane GO:0030672 ISO
    protein-containing complex GO:0032991 IDA
    terminal bouton GO:0043195 IDA
    terminal bouton GO:0043195 IEA
    terminal bouton GO:0043195 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
    presynaptic active zone GO:0048786 IEA
    presynaptic active zone GO:0048786 ISO
    presynaptic active zone GO:0048786 ISS
    presynapse GO:0098793 ISO
    postsynapse GO:0098794 IEA
    postsynapse GO:0098794 ISO
    postsynapse GO:0098794 ISS
 Experiment description of studies that identified Rab3a in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Rab3a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rph3al  
Reconstituted Complex Rattus norvegicus
2 STXBP5L  
Affinity Capture-MS Homo sapiens
3 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
4 Rims2  
Reconstituted Complex Rattus norvegicus
View the network image/svg+xml



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