Gene description for Tgfbr1
Gene name	transforming growth factor, beta receptor I
Gene symbol	Tgfbr1
Other names/aliases	ALK5 AU017191 Alk-5 TbetaR-I TbetaRI
Species	Mus musculus
Database cross references - Tgfbr1
ExoCarta	ExoCarta_21812
Vesiclepedia	VP_21812
Entrez Gene	21812
UniProt	Q64729
Tgfbr1 identified in sEVs derived from the following tissue/cell type
Breast cancer cells	34112803
Breast cancer cells	34112803

Gene ontology annotations for Tgfbr1

Molecular Function     protein kinase activity GO:0004672 ISO     protein serine/threonine kinase activity GO:0004674 ISO     transmembrane receptor protein serine/threonine kinase activity GO:0004675 ISO     transforming growth factor beta receptor activity GO:0005024 IDA     transforming growth factor beta receptor activity GO:0005024 IGI     transforming growth factor beta receptor activity GO:0005024 ISO     transforming growth factor beta receptor activity GO:0005024 ISO     transforming growth factor beta receptor activity, type I GO:0005025 IBA     transforming growth factor beta receptor activity, type I GO:0005025 ISO     transforming growth factor beta receptor activity, type I GO:0005025 ISS     transforming growth factor beta receptor activity, type II GO:0005026 IEA     signaling receptor binding GO:0005102 IPI     type II transforming growth factor beta receptor binding GO:0005114 IEA     type II transforming growth factor beta receptor binding GO:0005114 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ATP binding GO:0005524 ISO     activin receptor activity, type I GO:0016361 IBA     activin receptor activity, type I GO:0016361 IEA     activin receptor activity, type II GO:0016362 IEA     growth factor binding GO:0019838 ISO     ubiquitin protein ligase binding GO:0031625 IEA     ubiquitin protein ligase binding GO:0031625 ISO     protein-containing complex binding GO:0044877 ISO     SMAD binding GO:0046332 IBA     SMAD binding GO:0046332 IDA     SMAD binding GO:0046332 ISO     metal ion binding GO:0046872 IEA     activin binding GO:0048185 IBA     transforming growth factor beta binding GO:0050431 IPI     transforming growth factor beta binding GO:0050431 ISO     transforming growth factor beta binding GO:0050431 ISO     transforming growth factor beta binding GO:0050431 ISS     transforming growth factor beta receptor activity, type III GO:0070123 IEA     I-SMAD binding GO:0070411 IEA     I-SMAD binding GO:0070411 ISO     BMP receptor activity GO:0098821 IEA Biological Process     skeletal system development GO:0001501 IGI     angiogenesis GO:0001525 IMP     in utero embryonic development GO:0001701 IMP     kidney development GO:0001822 IGI     blastocyst development GO:0001824 IDA     epithelial to mesenchymal transition GO:0001837 ISO     endothelial cell proliferation GO:0001935 IGI     negative regulation of endothelial cell proliferation GO:0001937 IGI     positive regulation of endothelial cell proliferation GO:0001938 ISS     lens development in camera-type eye GO:0002088 IMP     ventricular trabecula myocardium morphogenesis GO:0003222 IMP     ventricular compact myocardium morphogenesis GO:0003223 IMP     proepicardium development GO:0003342 IMP     regulation of DNA-templated transcription GO:0006355 ISO     apoptotic process GO:0006915 IMP     signal transduction GO:0007165 ISO     transforming growth factor beta receptor signaling pathway GO:0007179 IBA     transforming growth factor beta receptor signaling pathway GO:0007179 IDA     transforming growth factor beta receptor signaling pathway GO:0007179 IGI     transforming growth factor beta receptor signaling pathway GO:0007179 IMP     transforming growth factor beta receptor signaling pathway GO:0007179 ISO     transforming growth factor beta receptor signaling pathway GO:0007179 ISS     nervous system development GO:0007399 IBA     heart development GO:0007507 IBA     heart development GO:0007507 IMP     heart development GO:0007507 ISS     positive regulation of cell population proliferation GO:0008284 ISO     germ cell migration GO:0008354 IMP     male gonad development GO:0008584 IMP     embryo development GO:0009790 IMP     post-embryonic development GO:0009791 IMP     anterior/posterior pattern specification GO:0009952 IGI     regulation of gene expression GO:0010468 IMP     regulation of gene expression GO:0010468 ISS     positive regulation of gene expression GO:0010628 ISO     positive regulation of gene expression GO:0010628 ISS     regulation of epithelial to mesenchymal transition GO:0010717 ISS     positive regulation of epithelial to mesenchymal transition GO:0010718 IGI     peptidyl-serine phosphorylation GO:0018105 ISO     collagen fibril organization GO:0030199 IMP     positive regulation of cell growth GO:0030307 IEA     positive regulation of cell growth GO:0030307 ISO     positive regulation of cell migration GO:0030335 IEA     positive regulation of cell migration GO:0030335 ISO     negative regulation of cell migration GO:0030336 IEA     negative regulation of cell migration GO:0030336 ISO     BMP signaling pathway GO:0030509 IEA     regulation of protein ubiquitination GO:0031396 IEA     regulation of protein ubiquitination GO:0031396 ISO     negative regulation of chondrocyte differentiation GO:0032331 IMP     activin receptor signaling pathway GO:0032924 IBA     activin receptor signaling pathway GO:0032924 ISS     intracellular signal transduction GO:0035556 ISS     myofibroblast differentiation GO:0036446 IEA     myofibroblast differentiation GO:0036446 ISO     endothelial cell activation GO:0042118 ISS     positive regulation of apoptotic process GO:0043065 IDA     negative regulation of apoptotic process GO:0043066 IMP     regulation of protein binding GO:0043393 IMP     endothelial cell migration GO:0043542 IMP     response to estrogen GO:0043627 ISO     negative regulation of endothelial cell differentiation GO:0045602 ISO     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of DNA-templated transcription GO:0045893 ISS     filopodium assembly GO:0046847 IMP     thymus development GO:0048538 IMP     neuron fate commitment GO:0048663 IMP     embryonic cranial skeleton morphogenesis GO:0048701 IMP     skeletal system morphogenesis GO:0048705 IGI     mesenchymal cell differentiation GO:0048762 ISS     artery morphogenesis GO:0048844 IMP     cell motility GO:0048870 ISO     positive regulation of filopodium assembly GO:0051491 IMP     positive regulation of stress fiber assembly GO:0051496 IGI     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     parathyroid gland development GO:0060017 IMP     roof of mouth development GO:0060021 IGI     roof of mouth development GO:0060021 IMP     pharyngeal system development GO:0060037 IMP     regulation of cardiac muscle cell proliferation GO:0060043 IMP     cardiac epithelial to mesenchymal transition GO:0060317 ISS     positive regulation of SMAD protein signal transduction GO:0060391 IEA     positive regulation of SMAD protein signal transduction GO:0060391 ISO     SMAD protein signal transduction GO:0060395 ISO     ventricular septum morphogenesis GO:0060412 IMP     angiogenesis involved in coronary vascular morphogenesis GO:0060978 IMP     coronary artery morphogenesis GO:0060982 IMP     response to cholesterol GO:0070723 IDA     response to cholesterol GO:0070723 ISO     cellular response to growth factor stimulus GO:0071363 IBA     cellular response to transforming growth factor beta stimulus GO:0071560 IDA     cellular response to transforming growth factor beta stimulus GO:0071560 ISO     vascular endothelial cell proliferation GO:0101023 IBA     positive regulation of extracellular matrix assembly GO:1901203 IEA     positive regulation of extracellular matrix assembly GO:1901203 ISO     positive regulation of mesenchymal stem cell proliferation GO:1902462 IEA     positive regulation of mesenchymal stem cell proliferation GO:1902462 ISO     negative regulation of miRNA transcription GO:1902894 ISO     positive regulation of miRNA transcription GO:1902895 ISO     positive regulation of vasculature development GO:1904018 IEA     positive regulation of vasculature development GO:1904018 ISO     positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 IMP     positive regulation of tight junction disassembly GO:1905075 IGI     epicardium morphogenesis GO:1905223 IMP     positive regulation of apoptotic signaling pathway GO:2001235 IEA     positive regulation of apoptotic signaling pathway GO:2001235 ISO     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IEA     negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO Subcellular Localization     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     endosome GO:0005768 IDA     endosome GO:0005768 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     plasma membrane GO:0005886 NAS     caveola GO:0005901 ISO     bicellular tight junction GO:0005923 IEA     bicellular tight junction GO:0005923 ISO     cell surface GO:0009986 ISO     cell surface GO:0009986 ISS     membrane GO:0016020 ISS     basolateral plasma membrane GO:0016323 ISO     apical plasma membrane GO:0016324 ISO     protein-containing complex GO:0032991 ISO     receptor complex GO:0043235 ISO     membrane raft GO:0045121 ISO     membrane raft GO:0045121 ISS     activin receptor complex GO:0048179 IBA     transforming growth factor beta ligand-receptor complex GO:0070021 ISO     transforming growth factor beta ligand-receptor complex GO:0070021 ISS