Gene description for P2rx7
Gene name	purinergic receptor P2X, ligand-gated ion channel, 7
Gene symbol	P2rx7
Other names/aliases	AI467586 P2X(7) P2X7R
Species	Mus musculus
Database cross references - P2rx7
ExoCarta	ExoCarta_18439
Vesiclepedia	VP_18439
Entrez Gene	18439
UniProt	Q9Z1M0
P2rx7 identified in sEVs derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846

Gene ontology annotations for P2rx7

Molecular Function     magnesium ion binding GO:0000287 ISO     lipopolysaccharide binding GO:0001530 IDA     purinergic nucleotide receptor activity GO:0001614 IEA     purinergic nucleotide receptor activity GO:0001614 ISO     extracellularly ATP-gated monoatomic cation channel activity GO:0004931 IBA     extracellularly ATP-gated monoatomic cation channel activity GO:0004931 IEA     extracellularly ATP-gated monoatomic cation channel activity GO:0004931 IMP     extracellularly ATP-gated monoatomic cation channel activity GO:0004931 ISO     signaling receptor binding GO:0005102 ISO     monoatomic ion channel activity GO:0005216 IEA     copper ion binding GO:0005507 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ATP binding GO:0005524 IMP     ATP binding GO:0005524 ISO     zinc ion binding GO:0008270 ISO     channel activity GO:0015267 IMP     channel activity GO:0015267 ISO     signaling receptor activity GO:0038023 IMP     identical protein binding GO:0042802 IPI     identical protein binding GO:0042802 ISO     protein serine/threonine kinase activator activity GO:0043539 ISO     scaffold protein binding GO:0097110 ISO Biological Process     MAPK cascade GO:0000165 IMP     cell morphogenesis GO:0000902 IMP     phagolysosome assembly GO:0001845 IMP     T cell mediated cytotoxicity GO:0001913 IMP     positive regulation of T cell mediated cytotoxicity GO:0001916 IMP     positive regulation of protein phosphorylation GO:0001934 IMP     positive regulation of protein phosphorylation GO:0001934 ISO     regulation of sodium ion transport GO:0002028 ISO     protein phosphorylation GO:0006468 IMP     membrane protein ectodomain proteolysis GO:0006509 IMP     phospholipid transfer to membrane GO:0006649 IMP     monoatomic cation transport GO:0006812 IMP     calcium ion transport GO:0006816 IMP     cell volume homeostasis GO:0006884 IDA     vesicle budding from membrane GO:0006900 IMP     inflammatory response GO:0006954 IMP     mitochondrion organization GO:0007005 IDA     plasma membrane organization GO:0007009 IDA     cell surface receptor signaling pathway GO:0007166 IBA     cell surface receptor signaling pathway GO:0007166 ISO     protein secretion GO:0009306 IDA     response to xenobiotic stimulus GO:0009410 IMP     response to mechanical stimulus GO:0009612 IMP     response to bacterium GO:0009617 IMP     response to zinc ion GO:0010043 IMP     gene expression GO:0010467 IMP     positive regulation of calcium ion transport into cytosol GO:0010524 IEA     positive regulation of calcium ion transport into cytosol GO:0010524 ISO     positive regulation of gene expression GO:0010628 ISO     macrophage cytokine production GO:0010934 IMP     programmed cell death GO:0012501 IDA     programmed cell death GO:0012501 IMP     glutamate secretion GO:0014047 IMP     positive regulation of glutamate secretion GO:0014049 IMP     gamma-aminobutyric acid secretion GO:0014051 IMP     positive regulation of gamma-aminobutyric acid secretion GO:0014054 IMP     response to organic cyclic compound GO:0014070 IDA     synaptic vesicle exocytosis GO:0016079 IMP     protein processing GO:0016485 IMP     plasma membrane phospholipid scrambling GO:0017121 IEA     plasma membrane phospholipid scrambling GO:0017121 ISO     neuronal action potential GO:0019228 ISO     sensory perception of pain GO:0019233 IMP     protein catabolic process GO:0030163 IDA     positive regulation of bone mineralization GO:0030501 IMP     bleb assembly GO:0032060 IMP     bleb assembly GO:0032060 IMP     bleb assembly GO:0032060 ISO     positive regulation of prostaglandin secretion GO:0032308 IMP     prostaglandin secretion GO:0032310 IMP     response to lipopolysaccharide GO:0032496 IDA     response to lipopolysaccharide GO:0032496 IMP     interleukin-1 alpha production GO:0032610 IMP     interleukin-1 beta production GO:0032611 IMP     interleukin-6 production GO:0032635 IMP     positive regulation of interleukin-1 alpha production GO:0032730 IMP     positive regulation of interleukin-1 beta production GO:0032731 IMP     positive regulation of interleukin-1 beta production GO:0032731 ISO     positive regulation of interleukin-6 production GO:0032755 IMP     collagen metabolic process GO:0032963 IMP     response to ATP GO:0033198 IDA     response to ATP GO:0033198 IEA     response to ATP GO:0033198 IMP     response to ATP GO:0033198 ISO     monoatomic ion transmembrane transport GO:0034220 IEA     response to fluid shear stress GO:0034405 IMP     positive regulation of monoatomic ion transmembrane transport GO:0034767 ISO     purinergic nucleotide receptor signaling pathway GO:0035590 IEA     purinergic nucleotide receptor signaling pathway GO:0035590 ISO     T cell proliferation GO:0042098 IMP     T cell homeostasis GO:0043029 IMP     positive regulation of apoptotic process GO:0043065 IMP     positive regulation of catalytic activity GO:0043085 IMP     NAD transport GO:0043132 IMP     positive regulation of MAP kinase activity GO:0043406 IMP     negative regulation of MAPK cascade GO:0043409 IDA     positive regulation of MAPK cascade GO:0043410 IMP     phospholipid translocation GO:0045332 IDA     positive regulation of ossification GO:0045778 IMP     negative regulation of bone resorption GO:0045779 IMP     negative regulation of cell volume GO:0045794 IMP     negative regulation of cell volume GO:0045794 ISO     positive regulation of glycolytic process GO:0045821 IEA     positive regulation of glycolytic process GO:0045821 ISO     ceramide biosynthetic process GO:0046513 IDA     pore complex assembly GO:0046931 IMP     pore complex assembly GO:0046931 ISO     skeletal system morphogenesis GO:0048705 IMP     homeostasis of number of cells within a tissue GO:0048873 IMP     positive regulation of protein secretion GO:0050714 IDA     defense response to Gram-positive bacterium GO:0050830 IMP     release of sequestered calcium ion into cytosol GO:0051209 IMP     positive regulation of cytoskeleton organization GO:0051495 ISO     response to calcium ion GO:0051592 IDA     response to calcium ion GO:0051592 IMP     response to electrical stimulus GO:0051602 IMP     establishment of localization in cell GO:0051649 IDA     establishment of localization in cell GO:0051649 IDA     establishment of localization in cell GO:0051649 IMP     establishment of localization in cell GO:0051649 IMP     cellular response to stimulus GO:0051716 IMP     mitochondrial depolarization GO:0051882 IMP     membrane depolarization GO:0051899 ISO     positive regulation of mitochondrial depolarization GO:0051901 IMP     excitatory postsynaptic potential GO:0060079 IEA     positive regulation of macrophage cytokine production GO:0060907 IMP     lymphocyte apoptotic process GO:0070227 IMP     positive regulation of lymphocyte apoptotic process GO:0070230 IMP     T cell apoptotic process GO:0070231 IMP     positive regulation of T cell apoptotic process GO:0070234 IMP     calcium ion transmembrane transport GO:0070588 IBA     cellular response to dsRNA GO:0071359 IMP     cellular response to organic cyclic compound GO:0071407 IDA     reactive oxygen species metabolic process GO:0072593 IMP     apoptotic signaling pathway GO:0097190 ISO     extrinsic apoptotic signaling pathway GO:0097191 IMP     extrinsic apoptotic signaling pathway GO:0097191 ISO     monoatomic cation transmembrane transport GO:0098655 IEA     regulation of presynaptic dense core granule exocytosis GO:0099161 ISO     positive regulation of NLRP3 inflammasome complex assembly GO:1900227 IMP     positive regulation of bleb assembly GO:1904172 IEA     positive regulation of bleb assembly GO:1904172 ISO     ATP export GO:1904669 ISO Subcellular Localization     nuclear envelope GO:0005635 ISO     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 IEA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 IMP     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     cell-cell junction GO:0005911 IDA     external side of plasma membrane GO:0009897 IDA     membrane GO:0016020 IDA     membrane GO:0016020 IEA     membrane GO:0016020 ISO     neuromuscular junction GO:0031594 IDA     neuromuscular junction GO:0031594 IPI     bleb GO:0032059 ISO     protein-containing complex GO:0032991 ISO     neuronal cell body GO:0043025 IDA     terminal bouton GO:0043195 ISO     synapse GO:0045202 IDA     presynapse GO:0098793 IEA     postsynapse GO:0098794 IEA