Gene description for Il6st
Gene name	interleukin 6 signal transducer
Gene symbol	Il6st
Other names/aliases	5133400A03Rik AA389424 BB405851 CD130 D13Ertd699e gp130
Species	Mus musculus
Database cross references - Il6st
ExoCarta	ExoCarta_16195
Vesiclepedia	VP_16195
Entrez Gene	16195
UniProt	Q00560
Il6st identified in sEVs derived from the following tissue/cell type
Breast cancer cells	34112803
Breast cancer cells	34112803

Gene ontology annotations for Il6st

Molecular Function     cytokine receptor activity GO:0004896 IBA     ciliary neurotrophic factor receptor activity GO:0004897 ISO     interleukin-6 receptor activity GO:0004915 IBA     interleukin-6 receptor activity GO:0004915 IEA     interleukin-6 receptor activity GO:0004915 ISO     interleukin-11 receptor activity GO:0004921 IDA     leukemia inhibitory factor receptor activity GO:0004923 IEA     leukemia inhibitory factor receptor activity GO:0004923 ISO     oncostatin-M receptor activity GO:0004924 IEA     oncostatin-M receptor activity GO:0004924 ISO     ciliary neurotrophic factor receptor binding GO:0005127 IEA     ciliary neurotrophic factor receptor binding GO:0005127 ISO     interleukin-6 receptor binding GO:0005138 IEA     interleukin-6 receptor binding GO:0005138 ISO     protein binding GO:0005515 IPI     coreceptor activity GO:0015026 IEA     coreceptor activity GO:0015026 ISO     growth factor binding GO:0019838 ISO     growth factor binding GO:0019838 ISO     cytokine binding GO:0019955 IBA     interleukin-11 binding GO:0019970 IDA     interleukin-6 binding GO:0019981 IBA     interleukin-6 binding GO:0019981 IEA     interleukin-6 binding GO:0019981 ISO     protein tyrosine kinase activator activity GO:0030296 IEA     protein tyrosine kinase activator activity GO:0030296 ISO     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     scaffold protein binding GO:0097110 IEA     scaffold protein binding GO:0097110 ISO Biological Process     glycogen metabolic process GO:0005977 IMP     triglyceride mobilization GO:0006642 ISO     signal transduction GO:0007165 IDA     positive regulation of cell population proliferation GO:0008284 IBA     positive regulation of cell population proliferation GO:0008284 IGI     positive regulation of cell population proliferation GO:0008284 ISO     regulation of Notch signaling pathway GO:0008593 IDA     positive regulation of smooth muscle cell migration GO:0014911 ISO     cytokine-mediated signaling pathway GO:0019221 IBA     cytokine-mediated signaling pathway GO:0019221 IDA     cytokine-mediated signaling pathway GO:0019221 ISO     response to cytokine GO:0034097 ISO     interleukin-11-mediated signaling pathway GO:0038154 IEA     interleukin-11-mediated signaling pathway GO:0038154 ISO     oncostatin-M-mediated signaling pathway GO:0038165 IEA     oncostatin-M-mediated signaling pathway GO:0038165 ISO     positive regulation of T cell proliferation GO:0042102 IEA     positive regulation of T cell proliferation GO:0042102 ISO     positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 ISO     negative regulation of neuron apoptotic process GO:0043524 IEA     negative regulation of neuron apoptotic process GO:0043524 ISO     positive regulation of osteoblast differentiation GO:0045669 IEA     positive regulation of osteoblast differentiation GO:0045669 ISO     positive regulation of Notch signaling pathway GO:0045747 IDA     positive regulation of Notch signaling pathway GO:0045747 ISO     positive regulation of astrocyte differentiation GO:0048711 IMP     leukemia inhibitory factor signaling pathway GO:0048861 IEA     leukemia inhibitory factor signaling pathway GO:0048861 ISO     negative regulation of cytosolic calcium ion concentration GO:0051481 ISO     intestinal epithelial cell development GO:0060576 IDA     intestinal epithelial cell development GO:0060576 ISO     interleukin-6-mediated signaling pathway GO:0070102 IDA     interleukin-6-mediated signaling pathway GO:0070102 ISO     negative regulation of interleukin-6-mediated signaling pathway GO:0070104 ISO     interleukin-27-mediated signaling pathway GO:0070106 IEA     interleukin-27-mediated signaling pathway GO:0070106 ISO     ciliary neurotrophic factor-mediated signaling pathway GO:0070120 IEA     ciliary neurotrophic factor-mediated signaling pathway GO:0070120 ISO     cell surface receptor signaling pathway via STAT GO:0097696 IEA Subcellular Localization     extracellular space GO:0005615 ISO     plasma membrane GO:0005886 ISO     interleukin-6 receptor complex GO:0005896 IEA     interleukin-6 receptor complex GO:0005896 ISO     oncostatin-M receptor complex GO:0005900 IEA     oncostatin-M receptor complex GO:0005900 ISO     external side of plasma membrane GO:0009897 IBA     external side of plasma membrane GO:0009897 IDA     dendrite GO:0030425 IDA     neuronal cell body membrane GO:0032809 ISO     neuronal cell body GO:0043025 IDA     receptor complex GO:0043235 IBA     cell body GO:0044297 IDA     membrane raft GO:0045121 IEA     membrane raft GO:0045121 ISO     ciliary neurotrophic factor receptor complex GO:0070110 IEA     ciliary neurotrophic factor receptor complex GO:0070110 ISO