Gene description for Il17ra
Gene name interleukin 17 receptor A
Gene symbol Il17ra
Other names/aliases AW538159
Cdw217
Il17r
VDw217
Species Mus musculus
 Database cross references - Il17ra
ExoCarta ExoCarta_16172
Vesiclepedia VP_16172
Entrez Gene 16172
UniProt Q60943  
 Il17ra identified in sEVs derived from the following tissue/cell type
Breast cancer cells 34112803    
Breast cancer cells 34112803    
 Gene ontology annotations for Il17ra
Molecular Function
    signaling receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
    interleukin-17 receptor activity GO:0030368 IBA
    interleukin-17 receptor activity GO:0030368 IDA
    interleukin-17 receptor activity GO:0030368 ISO
Biological Process
    inflammatory response GO:0006954 IEA
    response to virus GO:0009615 IDA
    response to virus GO:0009615 ISO
    protein catabolic process GO:0030163 IDA
    positive regulation of interleukin-13 production GO:0032736 IMP
    positive regulation of interleukin-23 production GO:0032747 IEA
    positive regulation of interleukin-23 production GO:0032747 ISO
    positive regulation of interleukin-5 production GO:0032754 IMP
    positive regulation of interleukin-6 production GO:0032755 IEA
    positive regulation of interleukin-6 production GO:0032755 ISO
    interleukin-17A-mediated signaling pathway GO:0038173 IEA
    interleukin-17A-mediated signaling pathway GO:0038173 ISO
    innate immune response GO:0045087 IEA
    positive regulation of inflammatory response GO:0050729 IDA
    positive regulation of inflammatory response GO:0050729 IMP
    positive regulation of inflammatory response GO:0050729 ISO
    defense response to fungus GO:0050832 IMP
    cellular response to cytokine stimulus GO:0071345 ISO
    granulocyte chemotaxis GO:0071621 IMP
    fibroblast activation GO:0072537 IEA
    fibroblast activation GO:0072537 ISO
    T-helper 17 type immune response GO:0072538 IDA
    interleukin-17-mediated signaling pathway GO:0097400 IDA
    interleukin-17-mediated signaling pathway GO:0097400 ISO
    positive regulation of cytokine production involved in inflammatory response GO:1900017 IDA
    positive regulation of cytokine production involved in inflammatory response GO:1900017 IGI
    positive regulation of cytokine production involved in inflammatory response GO:1900017 ISO
    positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 IEA
    positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 ISO
Subcellular Localization
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified Il17ra in sEVs
1
Experiment ID 520
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Cd9
Enriched markers
✔
Golga2
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34112803    
Organism Mus musculus
Experiment description Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors "Lima LG, Ham S, Shin H, Chai EPZ, Lek ESH, Lobb RJ, Müller AF, Mathivanan S, Yeo B, Choi Y, Parker BS, Möller A. "
Journal name Nat Commun
Publication year 2021
Sample Breast cancer cells
Sample name EO771
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 521
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Cd9
Enriched markers
✔
Golga2
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34112803    
Organism Mus musculus
Experiment description Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors "Lima LG, Ham S, Shin H, Chai EPZ, Lek ESH, Lobb RJ, Müller AF, Mathivanan S, Yeo B, Choi Y, Parker BS, Möller A. "
Journal name Nat Commun
Publication year 2021
Sample Breast cancer cells
Sample name PyMT
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for Il17ra
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Il17rc  
Affinity Capture-Western Mus musculus
2 TNFAIP3 7128
Affinity Capture-Western Homo sapiens
3 Traf3ip2  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
4 Il16  
Co-fractionation Mus musculus
5 Traf6  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Il17ra is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here