ExoCarta: Gene summary

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Gene description for COPA
Gene name	coatomer protein complex, subunit alpha
Gene symbol	COPA
Other names/aliases	-
Species	Bos taurus
Database cross references - COPA
ExoCarta	ExoCarta_100126041
Vesiclepedia	VP_100126041
Entrez Gene	100126041
UniProt	Q27954
COPA identified in sEVs derived from the following tissue/cell type
Milk	23459212

Gene ontology annotations for COPA

Molecular Function
	structural molecule activity	GO:0005198	IEA
	protein binding	GO:0005515	IEA
Biological Process
	intracellular protein transport	GO:0006886	IEA
	endoplasmic reticulum to Golgi vesicle-mediated transport	GO:0006888	IEA
	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	GO:0006890	IEA
	intra-Golgi vesicle-mediated transport	GO:0006891	IEA
Subcellular Localization
	COPI vesicle coat	GO:0030126	IEA

Experiment description of studies that identified COPA in sEVs

Experiment ID

213

MISEV standards
✘	Biophysical techniques
✘	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

23459212

Organism

Bos taurus

Experiment description

"Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis."

Authors

"Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD."

Journal name

J Proteomics

Publication year

2013

Sample

Milk

Sample name

Staphylococcus aureus-infected-Milk

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for COPA

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

KDELR1

10945

Protein-peptide

Homo sapiens

View the network

Pathways in which COPA is involved

Pathway	Evidence	Source
Asparagine N-linked glycosylation	IEA	Reactome
COPI-dependent Golgi-to-ER retrograde traffic	IEA	Reactome
COPI-mediated anterograde transport	IEA	Reactome
ER to Golgi Anterograde Transport	IEA	Reactome
Golgi-to-ER retrograde transport	IEA	Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic	IEA	Reactome
Membrane Trafficking	IEA	Reactome
Metabolism of proteins	IEA	Reactome
Post-translational protein modification	IEA	Reactome
Transport to the Golgi and subsequent modification	IEA	Reactome
Vesicle-mediated transport	IEA	Reactome

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