Gene description for Pdgfra
Gene name	platelet derived growth factor receptor, alpha polypeptide
Gene symbol	Pdgfra
Other names/aliases	AI115593 CD140a Pdgfr-2
Species	Mus musculus
Database cross references - Pdgfra
ExoCarta	ExoCarta_18595
Vesiclepedia	VP_18595
Entrez Gene	18595
UniProt	P26618
Pdgfra identified in sEVs derived from the following tissue/cell type
Breast cancer cells	34112803
Breast cancer cells	34112803
Fibroblasts	23260141

Gene ontology annotations for Pdgfra

Molecular Function     protein kinase activity GO:0004672 ISO     transmembrane receptor protein tyrosine kinase activity GO:0004714 ISO     GPI-linked ephrin receptor activity GO:0005004 IEA     transmembrane-ephrin receptor activity GO:0005005 IEA     epidermal growth factor receptor activity GO:0005006 IEA     fibroblast growth factor receptor activity GO:0005007 IEA     hepatocyte growth factor receptor activity GO:0005008 IEA     insulin receptor activity GO:0005009 IEA     insulin-like growth factor receptor activity GO:0005010 IEA     macrophage colony-stimulating factor receptor activity GO:0005011 IEA     platelet-derived growth factor alpha-receptor activity GO:0005018 IBA     platelet-derived growth factor alpha-receptor activity GO:0005018 IDA     platelet-derived growth factor alpha-receptor activity GO:0005018 ISO     platelet-derived growth factor alpha-receptor activity GO:0005018 ISS     platelet-derived growth factor beta-receptor activity GO:0005019 IEA     stem cell factor receptor activity GO:0005020 IEA     vascular endothelial growth factor receptor activity GO:0005021 ISO     vascular endothelial growth factor receptor activity GO:0005021 ISS     platelet-derived growth factor receptor binding GO:0005161 IEA     platelet-derived growth factor receptor binding GO:0005161 ISO     ATP binding GO:0005524 IEA     boss receptor activity GO:0008288 IEA     histone H3Y41 kinase activity GO:0035401 IEA     placental growth factor receptor activity GO:0036332 IEA     protein tyrosine kinase collagen receptor activity GO:0038062 IEA     vascular endothelial growth factor binding GO:0038085 IEA     vascular endothelial growth factor binding GO:0038085 ISO     protein homodimerization activity GO:0042803 ISO     protein homodimerization activity GO:0042803 ISS     phosphatidylinositol 3-kinase binding GO:0043548 ISO     protein-containing complex binding GO:0044877 IDA     platelet-derived growth factor binding GO:0048407 IBA     platelet-derived growth factor binding GO:0048407 IDA     platelet-derived growth factor binding GO:0048407 ISO     platelet-derived growth factor binding GO:0048407 TAS     brain-derived neurotrophic factor receptor activity GO:0060175 IEA     histone H2AXY142 kinase activity GO:0140801 IEA     phospholipase C activator activity GO:0160185 IEA Biological Process     luteinization GO:0001553 IGI     luteinization GO:0001553 IMP     in utero embryonic development GO:0001701 IMP     hematopoietic progenitor cell differentiation GO:0002244 IMP     chromatin remodeling GO:0006338 IEA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     epidermal growth factor receptor signaling pathway GO:0007173 IEA     multicellular organism development GO:0007275 IBA     estrogen metabolic process GO:0008210 IGI     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of cell population proliferation GO:0008284 ISS     insulin receptor signaling pathway GO:0008286 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 IEA     female gonad development GO:0008585 IGI     anatomical structure morphogenesis GO:0009653 IMP     animal organ morphogenesis GO:0009887 IMP     negative regulation of platelet activation GO:0010544 ISO     negative regulation of platelet activation GO:0010544 ISS     cell migration GO:0016477 IMP     peptidyl-tyrosine phosphorylation GO:0018108 IDA     peptidyl-tyrosine phosphorylation GO:0018108 ISO     peptidyl-tyrosine phosphorylation GO:0018108 ISS     signal transduction involved in regulation of gene expression GO:0023019 IDA     extracellular matrix organization GO:0030198 IMP     lung development GO:0030324 IMP     adrenal gland development GO:0030325 IGI     positive regulation of cell migration GO:0030335 ISO     positive regulation of cell migration GO:0030335 ISS     male genitalia development GO:0030539 IMP     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA     Leydig cell differentiation GO:0033327 IMP     cellular response to reactive oxygen species GO:0034614 ISO     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IDA     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 ISO     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA     positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 ISO     positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 ISS     Kit signaling pathway GO:0038109 IEA     macrophage colony-stimulating factor signaling pathway GO:0038145 IEA     wound healing GO:0042060 IMP     odontogenesis of dentin-containing tooth GO:0042475 IMP     protein autophosphorylation GO:0046777 IDA     protein autophosphorylation GO:0046777 ISO     protein autophosphorylation GO:0046777 ISS     platelet-derived growth factor receptor signaling pathway GO:0048008 IMP     platelet-derived growth factor receptor signaling pathway GO:0048008 ISO     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     ephrin receptor signaling pathway GO:0048013 IEA     positive regulation of fibroblast proliferation GO:0048146 ISO     positive regulation of fibroblast proliferation GO:0048146 ISS     embryonic digestive tract morphogenesis GO:0048557 IMP     embryonic cranial skeleton morphogenesis GO:0048701 IBA     embryonic cranial skeleton morphogenesis GO:0048701 IMP     skeletal system morphogenesis GO:0048705 IMP     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     positive regulation of calcium-mediated signaling GO:0050850 ISO     positive regulation of calcium-mediated signaling GO:0050850 ISS     white fat cell differentiation GO:0050872 IMP     positive regulation of chemotaxis GO:0050921 IEA     positive regulation of chemotaxis GO:0050921 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     cardiac myofibril assembly GO:0055003 IGI     roof of mouth development GO:0060021 IMP     face morphogenesis GO:0060325 IMP     cell chemotaxis GO:0060326 IMP     cell chemotaxis GO:0060326 ISO     lung growth GO:0060437 ISO     positive regulation of branching involved in lung morphogenesis GO:0061047 ISO     retina vasculature development in camera-type eye GO:0061298 IGI     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     platelet aggregation GO:0070527 ISO     platelet aggregation GO:0070527 ISS     cellular response to amino acid stimulus GO:0071230 IDA     metanephric glomerular capillary formation GO:0072277 IGI     regulation of mesenchymal stem cell differentiation GO:2000739 ISO     regulation of mesenchymal stem cell differentiation GO:2000739 ISS Subcellular Localization     nucleus GO:0005634 IDA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     Golgi apparatus GO:0005794 IDA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     microvillus GO:0005902 IDA     cilium GO:0005929 IDA     external side of plasma membrane GO:0009897 IDA     cell surface GO:0009986 IDA     cell junction GO:0030054 IEA     cell junction GO:0030054 ISO     axon GO:0030424 ISO     protein-containing complex GO:0032991 ISO     receptor complex GO:0043235 IBA