Gene description for FGF19
Gene name fibroblast growth factor 19
Gene symbol FGF19
Other names/aliases -
Species Homo sapiens
 Database cross references - FGF19
ExoCarta ExoCarta_9965
Entrez Gene 9965
HGNC 3675
MIM 603891
UniProt O95750  
 FGF19 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for FGF19
Molecular Function
    fibroblast growth factor receptor binding GO:0005104 IPI
    growth factor activity GO:0008083 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    insulin receptor signaling pathway GO:0008286 TAS
    neural crest cell migration GO:0001755 IEA
    positive regulation of protein phosphorylation GO:0001934 IDA
    innate immune response GO:0045087 TAS
    positive regulation of JNK cascade GO:0046330 IDA
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    positive regulation of glucose import GO:0046326 IDA
    nervous system development GO:0007399 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    heart development GO:0007507 IEA
    positive regulation of cell proliferation GO:0008284 IGI
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    negative regulation of gene expression GO:0010629 IDA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    negative regulation of bile acid biosynthetic process GO:0070858 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    intracellular GO:0005622 TAS
 Experiment description of studies that identified FGF19 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for FGF19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FGFR4 2264
Reconstituted Complex Homo sapiens
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