Gene description for Nucks1
Gene name nuclear casein kinase and cyclin-dependent kinase substrate 1
Gene symbol Nucks1
Other names/aliases 2700010L10Rik
8430423A01Rik
AI647518
C78391
Nucks
Species Mus musculus
 Database cross references - Nucks1
ExoCarta ExoCarta_98415
Vesiclepedia VP_98415
Entrez Gene 98415
UniProt Q80XU3  
 Nucks1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Nucks1
Molecular Function
    chromatin binding GO:0003682 IEA
    chromatin binding GO:0003682 ISO
    double-stranded DNA binding GO:0003690 IBA
    double-stranded DNA binding GO:0003690 IEA
    double-stranded DNA binding GO:0003690 ISO
    single-stranded DNA binding GO:0003697 IBA
    single-stranded DNA binding GO:0003697 ISO
    transcription coactivator activity GO:0003713 IEA
    transcription coactivator activity GO:0003713 ISO
    DNA-binding transcription factor binding GO:0140297 IEA
    DNA-binding transcription factor binding GO:0140297 ISO
Biological Process
    double-strand break repair via homologous recombination GO:0000724 IBA
    double-strand break repair via homologous recombination GO:0000724 IEA
    double-strand break repair via homologous recombination GO:0000724 ISO
    intracellular glucose homeostasis GO:0001678 IMP
    regulation of DNA replication GO:0006275 IEA
    regulation of DNA replication GO:0006275 ISO
    chromatin organization GO:0006325 IMP
    regulation of transcription by RNA polymerase II GO:0006357 IC
    replication fork processing GO:0031297 IEA
    replication fork processing GO:0031297 ISO
    interstrand cross-link repair GO:0036297 IBA
    interstrand cross-link repair GO:0036297 IEA
    interstrand cross-link repair GO:0036297 ISO
    glucose homeostasis GO:0042593 IMP
    positive regulation by host of viral transcription GO:0043923 IEA
    positive regulation by host of viral transcription GO:0043923 ISO
    modulation by host of viral genome replication GO:0044827 ISO
    positive regulation by host of viral genome replication GO:0044829 IEA
    positive regulation by host of viral genome replication GO:0044829 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    regulation of insulin receptor signaling pathway GO:0046626 IMP
    positive regulation of insulin receptor signaling pathway GO:0046628 IMP
    regulation of DNA strand elongation GO:0060382 IEA
    regulation of DNA strand elongation GO:0060382 ISO
    cellular response to X-ray GO:0071481 IEA
    cellular response to X-ray GO:0071481 ISO
    modulation by host of RNA binding by virus GO:1990968 ISO
    modulation by host of viral RNA-binding transcription factor activity GO:1990969 IEA
    modulation by host of viral RNA-binding transcription factor activity GO:1990969 ISO
Subcellular Localization
    chromatin GO:0000785 IDA
    chromatin GO:0000785 ISO
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Nucks1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Nucks1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Nucks1 is involved
No pathways found





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