Gene description for Hist2h3c2
Gene name histone cluster 2, H3c2
Gene symbol Hist2h3c2
Other names/aliases H3-614
H3.2-614
Hist2h3c2-ps
Hist2h3ca1
M32461
Species Mus musculus
 Database cross references - Hist2h3c2
ExoCarta ExoCarta_97114
Vesiclepedia VP_97114
Entrez Gene 97114
UniProt P84228  
 Hist2h3c2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
Oligodendrocytes 21136642    
 Gene ontology annotations for Hist2h3c2
Subcellular Localization
    nucleosome GO:0000786 ISO
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    protein-containing complex GO:0032991 ISO
 Experiment description of studies that identified Hist2h3c2 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 33
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Hist2h3c2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atxn1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Hist2h3c2 is involved
PathwayEvidenceSource
Cell Cycle IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
Condensation of Prophase Chromosomes IEA Reactome
Cytokine Signaling in Immune system IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
ESR-mediated signaling IEA Reactome
Estrogen-dependent gene expression IEA Reactome
Factors involved in megakaryocyte development and platelet production IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
HATs acetylate histones IEA Reactome
HDACs deacetylate histones IEA Reactome
HDMs demethylate histones IEA Reactome
Hemostasis IEA Reactome
Immune System IEA Reactome
Interleukin-7 signaling IEA Reactome
M Phase IEA Reactome
Mitotic Prophase IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
PKMTs methylate histone lysines IEA Reactome
PRC2 methylates histones and DNA IEA Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
RMTs methylate histone arginines IEA Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function IEA Reactome
Signal Transduction IEA Reactome
Signaling by Interleukins IEA Reactome
Signaling by Nuclear Receptors IEA Reactome
Transcriptional regulation by RUNX1 IEA Reactome





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