Gene description for THEMIS2
Gene name thymocyte selection associated family member 2
Gene symbol THEMIS2
Other names/aliases C1orf38
ICB-1
Species Homo sapiens
 Database cross references - THEMIS2
ExoCarta ExoCarta_9473
Vesiclepedia VP_9473
Entrez Gene 9473
HGNC 16839
UniProt Q5TEJ8  
 THEMIS2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for THEMIS2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    inflammatory response GO:0006954 IEA
    cell adhesion GO:0007155 TAS
    T cell receptor signaling pathway GO:0050852 IBA
    regulation of B cell activation GO:0050864 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified THEMIS2 in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for THEMIS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPB2  
Two-hybrid Homo sapiens
2 EIF4E3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 NOTCH2NL 388677
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which THEMIS2 is involved
No pathways found





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