Gene description for Glce
Gene name glucuronyl C5-epimerase
Gene symbol Glce
Other names/aliases 1110017N23Rik
AI747411
C130034A12Rik
Hsepi
Species Mus musculus
 Database cross references - Glce
ExoCarta ExoCarta_93683
Vesiclepedia VP_93683
Entrez Gene 93683
UniProt Q9EPS3  
 Glce identified in sEVs derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Glce
Molecular Function
    calcium ion binding GO:0005509 ISO
    calcium ion binding GO:0005509 ISS
    racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016857 IDA
    racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016857 IMP
    protein homodimerization activity GO:0042803 ISO
    protein homodimerization activity GO:0042803 ISS
    heparosan-N-sulfate-glucuronate 5-epimerase activity GO:0047464 IBA
    heparosan-N-sulfate-glucuronate 5-epimerase activity GO:0047464 IDA
    heparosan-N-sulfate-glucuronate 5-epimerase activity GO:0047464 ISO
    heparosan-N-sulfate-glucuronate 5-epimerase activity GO:0047464 ISS
    UDP-glucuronate 5'-epimerase activity GO:0050379 TAS
Biological Process
    positive regulation of cell population proliferation GO:0008284 IEA
    positive regulation of cell population proliferation GO:0008284 ISO
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IBA
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IDA
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IEA
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IMP
    heparan sulfate proteoglycan biosynthetic process GO:0015012 ISO
    heparin biosynthetic process GO:0030210 IDA
    heparin biosynthetic process GO:0030210 IEA
    negative regulation of cell projection organization GO:0031345 IEA
    negative regulation of cell projection organization GO:0031345 ISO
    positive regulation of SMAD protein signal transduction GO:0060391 IEA
    positive regulation of SMAD protein signal transduction GO:0060391 ISO
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified Glce in sEVs
1
Experiment ID 263
MISEV standards
Biophysical techniques
CD63|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-? via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors "Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino"
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Glce
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Glce is involved
No pathways found





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