Gene description for CACNA2D4
Gene name calcium channel, voltage-dependent, alpha 2/delta subunit 4
Gene symbol CACNA2D4
Other names/aliases RCD4
Species Homo sapiens
 Database cross references - CACNA2D4
ExoCarta ExoCarta_93589
Entrez Gene 93589
HGNC 20202
MIM 608171
UniProt Q7Z3S7  
 CACNA2D4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CACNA2D4
Molecular Function
    calcium channel regulator activity GO:0005246 IBA
    voltage-gated calcium channel activity GO:0005245 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    regulation of ion transmembrane transport GO:0034765 IEA
    calcium ion transmembrane transport GO:0070588 IDA
    regulation of calcium ion transport GO:0051924 IBA
    detection of light stimulus involved in visual perception GO:0050908 IMP
Subcellular Localization
    voltage-gated calcium channel complex GO:0005891 IDA
 Experiment description of studies that identified CACNA2D4 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CACNA2D4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CACNA2D4 is involved
No pathways found





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