Gene description for Cxadr
Gene name coxsackie virus and adenovirus receptor
Gene symbol Cxadr
Other names/aliases Car1
Species Rattus norvegicus
 Database cross references - Cxadr
ExoCarta ExoCarta_89843
Vesiclepedia VP_89843
Entrez Gene 89843
UniProt Q9R066  
 Cxadr identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Cxadr
Molecular Function
    signaling receptor binding GO:0005102 ISO
    integrin binding GO:0005178 ISO
    beta-catenin binding GO:0008013 ISO
    beta-catenin binding GO:0008013 ISS
    PDZ domain binding GO:0030165 ISO
    PDZ domain binding GO:0030165 ISS
    identical protein binding GO:0042802 ISO
    cell adhesion molecule binding GO:0050839 IBA
    cell adhesion molecule binding GO:0050839 ISO
    cell adhesion molecule binding GO:0050839 ISS
    connexin binding GO:0071253 ISO
    connexin binding GO:0071253 ISS
Biological Process
    mitochondrion organization GO:0007005 ISO
    mitochondrion organization GO:0007005 ISS
    cell adhesion GO:0007155 IEA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISO
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISS
    heart development GO:0007507 ISO
    heart development GO:0007507 ISS
    germ cell migration GO:0008354 ISO
    germ cell migration GO:0008354 ISS
    epithelial structure maintenance GO:0010669 ISO
    epithelial structure maintenance GO:0010669 ISS
    actin cytoskeleton organization GO:0030036 ISO
    actin cytoskeleton organization GO:0030036 ISS
    neutrophil chemotaxis GO:0030593 ISO
    neutrophil chemotaxis GO:0030593 ISS
    homotypic cell-cell adhesion GO:0034109 IBA
    homotypic cell-cell adhesion GO:0034109 ISO
    homotypic cell-cell adhesion GO:0034109 ISS
    cell-cell junction organization GO:0045216 ISO
    cell-cell junction organization GO:0045216 ISS
    gamma-delta T cell activation GO:0046629 ISO
    gamma-delta T cell activation GO:0046629 ISS
    defense response to virus GO:0051607 ISO
    cardiac muscle cell development GO:0055013 ISO
    cardiac muscle cell development GO:0055013 ISS
    cardiac muscle cell proliferation GO:0060038 ISO
    negative regulation of cardiac muscle cell proliferation GO:0060044 ISO
    transepithelial transport GO:0070633 ISO
    AV node cell to bundle of His cell communication GO:0086067 ISO
    AV node cell to bundle of His cell communication GO:0086067 ISS
    AV node cell-bundle of His cell adhesion involved in cell communication GO:0086072 ISO
    cell-cell adhesion GO:0098609 ISO
    regulation of AV node cell action potential GO:0098904 ISO
    regulation of synaptic vesicle endocytosis GO:1900242 ISO
Subcellular Localization
    acrosomal vesicle GO:0001669 ISO
    acrosomal vesicle GO:0001669 ISS
    extracellular space GO:0005615 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    cell-cell junction GO:0005911 ISO
    adherens junction GO:0005912 ISO
    adherens junction GO:0005912 ISS
    bicellular tight junction GO:0005923 IBA
    bicellular tight junction GO:0005923 IDA
    bicellular tight junction GO:0005923 ISO
    intercalated disc GO:0014704 IBA
    intercalated disc GO:0014704 ISO
    basolateral plasma membrane GO:0016323 IBA
    basolateral plasma membrane GO:0016323 ISO
    apicolateral plasma membrane GO:0016327 ISO
    apicolateral plasma membrane GO:0016327 ISS
    cell junction GO:0030054 ISO
    filopodium GO:0030175 ISO
    filopodium GO:0030175 ISS
    growth cone GO:0030426 ISO
    growth cone GO:0030426 ISS
    neuromuscular junction GO:0031594 ISO
    protein-containing complex GO:0032991 ISO
    presynaptic membrane GO:0042734 ISO
    neuron projection GO:0043005 IDA
    neuron projection GO:0043005 ISO
    cell body GO:0044297 ISO
    cell body GO:0044297 ISS
    membrane raft GO:0045121 ISO
    membrane raft GO:0045121 ISS
    glutamatergic synapse GO:0098978 ISO
    GABA-ergic synapse GO:0098982 ISO
 Experiment description of studies that identified Cxadr in sEVs
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Cxadr
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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