Gene description for Nrtn
Gene name neurturin
Gene symbol Nrtn
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Nrtn
ExoCarta ExoCarta_84423
Vesiclepedia VP_84423
Entrez Gene 84423
 Nrtn identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Nrtn
Molecular Function
    growth factor activity GO:0008083 IBA
    growth factor activity GO:0008083 IDA
    growth factor activity GO:0008083 ISO
    glial cell-derived neurotrophic factor receptor binding GO:0030116 IEA
    receptor tyrosine kinase binding GO:0030971 IEA
    heparan sulfate binding GO:1904399 ISO
Biological Process
    neural crest cell migration GO:0001755 ISO
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 ISO
    biological_process GO:0008150 ND
    nerve development GO:0021675 ISO
    neuron projection development GO:0031175 ISO
    glial cell-derived neurotrophic factor receptor signaling pathway GO:0035860 ISO
Subcellular Localization
    extracellular space GO:0005615 ISO
    axon GO:0030424 IDA
 Experiment description of studies that identified Nrtn in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Nrtn
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Nrtn is involved
No pathways found





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