Gene description for SLC4A11
Gene name solute carrier family 4, sodium borate transporter, member 11
Gene symbol SLC4A11
Other names/aliases BTR1
CDPD1
CHED2
NABC1
dJ794I6.2
Species Homo sapiens
 Database cross references - SLC4A11
ExoCarta ExoCarta_83959
Vesiclepedia VP_83959
Entrez Gene 83959
HGNC 16438
MIM 610206
UniProt Q8NBS3  
 SLC4A11 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLC4A11
Molecular Function
    sodium channel activity GO:0005272 IDA
    water transmembrane transporter activity GO:0005372 IDA
    solute:inorganic anion antiporter activity GO:0005452 IEA
    proton transmembrane transporter activity GO:0015078 IDA
    bicarbonate transmembrane transporter activity GO:0015106 IDA
    proton channel activity GO:0015252 IDA
    symporter activity GO:0015293 IEA
    transmembrane transporter activity GO:0022857 IBA
    active borate transmembrane transporter activity GO:0046715 IDA
    protein dimerization activity GO:0046983 IDA
Biological Process
    sodium ion transport GO:0006814 IDA
    monoatomic anion transport GO:0006820 IEA
    water transport GO:0006833 IEA
    bicarbonate transport GO:0015701 IDA
    intracellular monoatomic cation homeostasis GO:0030003 IDA
    cellular response to oxidative stress GO:0034599 IMP
    borate transmembrane transport GO:0035445 IEA
    sodium ion transmembrane transport GO:0035725 IEA
    fluid transport GO:0042044 ISS
    borate transport GO:0046713 IDA
    monoatomic ion homeostasis GO:0050801 IBA
    regulation of mitochondrial membrane potential GO:0051881 IMP
    transmembrane transport GO:0055085 IBA
    cellular hypotonic response GO:0071476 IDA
    proton transmembrane transport GO:1902600 IDA
    regulation of mesenchymal stem cell differentiation GO:2000739 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    vesicle membrane GO:0012506 ISS
    basolateral plasma membrane GO:0016323 IBA
    basolateral plasma membrane GO:0016323 IDA
    basolateral plasma membrane GO:0016323 ISS
    basolateral plasma membrane GO:0016323 TAS
    apical plasma membrane GO:0016324 IDA
 Experiment description of studies that identified SLC4A11 in sEVs
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC4A11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRPF19 27339
Cross-Linking-MS (XL-MS) Homo sapiens
2 TAF1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLC4A11 is involved
No pathways found





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