Gene description for Abcb11
Gene name	ATP-binding cassette, subfamily B (MDR/TAP), member 11
Gene symbol	Abcb11
Other names/aliases	Bsep Spgp
Species	Rattus norvegicus
Database cross references - Abcb11
ExoCarta	ExoCarta_83569
Vesiclepedia	VP_83569
Entrez Gene	83569
UniProt	O70127
Abcb11 identified in sEVs derived from the following tissue/cell type
Hepatocytes	19367702

Gene ontology annotations for Abcb11

Molecular Function     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ABC-type xenobiotic transporter activity GO:0008559 IEA     ABC-type xenobiotic transporter activity GO:0008559 IMP     ABC-type xenobiotic transporter activity GO:0008559 ISO     ABC-type xenobiotic transporter activity GO:0008559 ISS     bile acid transmembrane transporter activity GO:0015125 IMP     bile acid transmembrane transporter activity GO:0015125 ISO     canalicular bile acid transmembrane transporter activity GO:0015126 IBA     canalicular bile acid transmembrane transporter activity GO:0015126 IDA     canalicular bile acid transmembrane transporter activity GO:0015126 IEA     canalicular bile acid transmembrane transporter activity GO:0015126 ISO     carbohydrate transmembrane transporter activity GO:0015144 IDA     ABC-type bile acid transporter activity GO:0015432 IBA     ABC-type bile acid transporter activity GO:0015432 IDA     ABC-type bile acid transporter activity GO:0015432 IEA     ABC-type bile acid transporter activity GO:0015432 IMP     ABC-type bile acid transporter activity GO:0015432 ISO     ABC-type bile acid transporter activity GO:0015432 ISS     ATP hydrolysis activity GO:0016887 IEA     ABC-type transporter activity GO:0140359 IEA Biological Process     fatty acid metabolic process GO:0006631 IEA     fatty acid metabolic process GO:0006631 ISO     fatty acid metabolic process GO:0006631 ISS     xenobiotic metabolic process GO:0006805 IEA     xenobiotic metabolic process GO:0006805 IMP     xenobiotic metabolic process GO:0006805 ISO     xenobiotic metabolic process GO:0006805 ISS     xenobiotic transmembrane transport GO:0006855 IEA     xenobiotic transmembrane transport GO:0006855 IMP     xenobiotic transmembrane transport GO:0006855 ISO     xenobiotic transmembrane transport GO:0006855 ISS     response to oxidative stress GO:0006979 IEP     bile acid metabolic process GO:0008206 IDA     bile acid metabolic process GO:0008206 IEA     bile acid metabolic process GO:0008206 ISO     response to xenobiotic stimulus GO:0009410 IMP     response to organic cyclic compound GO:0014070 IEP     bile acid and bile salt transport GO:0015721 IDA     bile acid and bile salt transport GO:0015721 IEP     bile acid and bile salt transport GO:0015721 IMP     bile acid and bile salt transport GO:0015721 ISO     canalicular bile acid transport GO:0015722 IBA     canalicular bile acid transport GO:0015722 IDA     canalicular bile acid transport GO:0015722 IEA     canalicular bile acid transport GO:0015722 IMP     canalicular bile acid transport GO:0015722 ISO     protein ubiquitination GO:0016567 IEA     protein ubiquitination GO:0016567 IMP     protein ubiquitination GO:0016567 ISO     protein ubiquitination GO:0016567 ISS     regulation of fatty acid beta-oxidation GO:0031998 IEA     regulation of fatty acid beta-oxidation GO:0031998 ISO     regulation of fatty acid beta-oxidation GO:0031998 ISS     carbohydrate transmembrane transport GO:0034219 IEA     cholesterol homeostasis GO:0042632 IEA     cholesterol homeostasis GO:0042632 ISO     cholesterol homeostasis GO:0042632 ISS     response to estrogen GO:0043627 IEP     response to ethanol GO:0045471 IEP     xenobiotic export from cell GO:0046618 IEA     xenobiotic export from cell GO:0046618 IMP     xenobiotic export from cell GO:0046618 ISO     xenobiotic export from cell GO:0046618 ISS     transmembrane transport GO:0055085 IBA     transmembrane transport GO:0055085 IDA     transmembrane transport GO:0055085 IEA     lipid homeostasis GO:0055088 ISO     lipid homeostasis GO:0055088 ISS     phospholipid homeostasis GO:0055091 IEA     phospholipid homeostasis GO:0055091 ISO     phospholipid homeostasis GO:0055091 ISS     cellular response to xenobiotic stimulus GO:0071466 IEP     positive regulation of bile acid secretion GO:0120189 IEA     positive regulation of bile acid secretion GO:0120189 ISO     positive regulation of bile acid secretion GO:0120189 ISS     regulation of bile acid metabolic process GO:1904251 IEA     regulation of bile acid metabolic process GO:1904251 ISO     regulation of bile acid metabolic process GO:1904251 ISS Subcellular Localization     Golgi membrane GO:0000139 IDA     endosome GO:0005768 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IMP     plasma membrane GO:0005886 ISO     cell surface GO:0009986 IEA     cell surface GO:0009986 ISO     cell surface GO:0009986 ISS     membrane GO:0016020 ISO     basolateral plasma membrane GO:0016323 IMP     apical plasma membrane GO:0016324 IBA     apical plasma membrane GO:0016324 IDA     apical plasma membrane GO:0016324 IEA     apical plasma membrane GO:0016324 ISO     apical part of cell GO:0045177 ISO     intercellular canaliculus GO:0046581 IEA     intercellular canaliculus GO:0046581 ISO     intracellular canaliculus GO:0046691 IDA     intracellular canaliculus GO:0046691 IMP     recycling endosome GO:0055037 IDA     recycling endosome membrane GO:0055038 IMP