Gene description for Plekha3
Gene name pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
Gene symbol Plekha3
Other names/aliases FAPP1
Species Mus musculus
 Database cross references - Plekha3
ExoCarta ExoCarta_83435
Vesiclepedia VP_83435
Entrez Gene 83435
UniProt Q9ERS4  
 Plekha3 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Plekha3
Molecular Function
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    phosphatidylinositol-4-phosphate binding GO:0070273 IEA
    phosphatidylinositol-4-phosphate binding GO:0070273 ISO
Biological Process
    receptor recycling GO:0001881 IBA
    endosome organization GO:0007032 IBA
    retrograde transport, endosome to Golgi GO:0042147 IBA
Subcellular Localization
    early endosome GO:0005769 IBA
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    trans-Golgi network GO:0005802 IBA
    membrane GO:0016020 IEA
    recycling endosome GO:0055037 IBA
 Experiment description of studies that identified Plekha3 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Plekha3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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