Gene description for Rab11a
Gene name RAB11a, member RAS oncogene family
Gene symbol Rab11a
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Rab11a
ExoCarta ExoCarta_81830
Vesiclepedia VP_81830
Entrez Gene 81830
UniProt P62494  
 Rab11a identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
Urine 20535238    
 Gene ontology annotations for Rab11a
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IDA
    GTPase activity GO:0003924 IEA
    GTPase activity GO:0003924 ISO
    GTPase activity GO:0003924 ISS
    G protein activity GO:0003925 ISO
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IDA
    GTP binding GO:0005525 IEA
    GTP binding GO:0005525 TAS
    microtubule binding GO:0008017 ISO
    protein domain specific binding GO:0019904 ISO
    myosin V binding GO:0031489 ISO
    dynein light intermediate chain binding GO:0051959 ISO
    dynein light intermediate chain binding GO:0051959 ISS
Biological Process
    exocytosis GO:0006887 IBA
    mitotic metaphase chromosome alignment GO:0007080 ISO
    positive regulation of epithelial cell migration GO:0010634 ISO
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 ISO
    protein transport GO:0015031 IEA
    vesicle-mediated transport GO:0016192 ISO
    astral microtubule organization GO:0030953 ISO
    neuron projection development GO:0031175 ISO
    neuron projection development GO:0031175 ISS
    intracellular cholesterol transport GO:0032367 ISS
    melanosome transport GO:0032402 IBA
    melanosome transport GO:0032402 ISO
    melanosome transport GO:0032402 ISS
    regulation of cytokinesis GO:0032465 ISO
    protein localization to cell surface GO:0034394 ISO
    multivesicular body assembly GO:0036258 ISO
    regulation of long-term neuronal synaptic plasticity GO:0048169 IMP
    regulation of protein transport GO:0051223 IMP
    establishment of vesicle localization GO:0051650 ISO
    regulation of vesicle-mediated transport GO:0060627 ISO
    early endosome to recycling endosome transport GO:0061502 ISO
    protein localization to cilium GO:0061512 ISO
    protein localization to cilium GO:0061512 ISS
    protein transmembrane transport GO:0071806 ISO
    establishment of protein localization to organelle GO:0072594 ISO
    protein localization to plasma membrane GO:0072659 ISO
    protein localization to plasma membrane GO:0072659 ISS
    establishment of protein localization to membrane GO:0090150 ISO
    mitotic spindle assembly GO:0090307 ISO
    neurotransmitter receptor transport, endosome to postsynaptic membrane GO:0098887 IBA
    neurotransmitter receptor transport, endosome to postsynaptic membrane GO:0098887 IDA
    neurotransmitter receptor transport, endosome to postsynaptic membrane GO:0098887 IMP
    vesicle-mediated transport in synapse GO:0099003 IDA
    vesicle-mediated transport in synapse GO:0099003 IMP
    synaptic vesicle endosomal processing GO:0099532 EXP
    synaptic vesicle endosomal processing GO:0099532 IDA
    synaptic vesicle endosomal processing GO:0099532 IMP
    amyloid-beta clearance by transcytosis GO:0150093 ISO
    regulation of cilium assembly GO:1902017 ISO
    regulation of cilium assembly GO:1902017 ISS
    regulation of early endosome to recycling endosome transport GO:1902954 ISO
    regulation of early endosome to recycling endosome transport GO:1902954 ISS
    positive regulation of protein localization to plasma membrane GO:1903078 IMP
    positive regulation of mitotic cytokinetic process GO:1903438 ISO
    regulation of protein localization to centrosome GO:1904779 ISO
    regulation of protein localization to centrosome GO:1904779 ISS
    exosomal secretion GO:1990182 ISO
    regulation of endocytic recycling GO:2001135 ISO
    regulation of endocytic recycling GO:2001135 ISS
Subcellular Localization
    Golgi membrane GO:0000139 ISO
    Golgi membrane GO:0000139 ISS
    spindle pole GO:0000922 ISO
    cytoplasm GO:0005737 ISO
    multivesicular body GO:0005771 ISO
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IEA
    trans-Golgi network GO:0005802 ISO
    trans-Golgi network GO:0005802 ISS
    centrosome GO:0005813 ISO
    centrosome GO:0005813 ISS
    centriole GO:0005814 ISO
    kinetochore microtubule GO:0005828 ISO
    cytosol GO:0005829 ISS
    membrane GO:0016020 ISO
    transport vesicle GO:0030133 IBA
    endocytic vesicle membrane GO:0030666 ISO
    endocytic vesicle membrane GO:0030666 ISS
    synaptic vesicle membrane GO:0030672 EXP
    synaptic vesicle membrane GO:0030672 IDA
    synaptic vesicle membrane GO:0030672 IEA
    cytoplasmic vesicle GO:0031410 ISO
    vesicle GO:0031982 ISO
    cleavage furrow GO:0032154 IEA
    cleavage furrow GO:0032154 ISO
    cleavage furrow GO:0032154 ISS
    trans-Golgi network membrane GO:0032588 ISO
    trans-Golgi network membrane GO:0032588 ISS
    protein-containing complex GO:0032991 ISO
    centriolar satellite GO:0034451 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    phagocytic vesicle GO:0045335 IEA
    phagocytic vesicle GO:0045335 ISO
    phagocytic vesicle GO:0045335 ISS
    perinuclear region of cytoplasm GO:0048471 ISO
    recycling endosome GO:0055037 IDA
    recycling endosome GO:0055037 ISO
    recycling endosome membrane GO:0055038 IEA
    extracellular exosome GO:0070062 ISO
    exocytic vesicle GO:0070382 ISO
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
    presynaptic endosome GO:0098830 EXP
    presynaptic endosome GO:0098830 IDA
    presynaptic endosome GO:0098830 IMP
    postsynaptic recycling endosome GO:0098837 IBA
    postsynaptic recycling endosome GO:0098837 ISO
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Rab11a in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
2
Experiment ID 192
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|HSP70|CD63|CD81|FLOT
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M."
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Rab11a
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KCNA5  
Affinity Capture-Western Homo sapiens
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