Gene description for C1qtnf3
Gene name C1q and tumor necrosis factor related protein 3
Gene symbol C1qtnf3
Other names/aliases 2310005P21Rik
CORS-26
CORS26
CTRP3
Corcs
Cors
Species Mus musculus
 Database cross references - C1qtnf3
ExoCarta ExoCarta_81799
Vesiclepedia VP_81799
Entrez Gene 81799
UniProt Q9ES30  
 C1qtnf3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for C1qtnf3
Molecular Function
    identical protein binding GO:0042802 IDA
    identical protein binding GO:0042802 ISO
Biological Process
    positive regulation of cytokine production GO:0001819 IDA
    positive regulation of cytokine production GO:0001819 ISO
    negative regulation of gene expression GO:0010629 ISO
    negative regulation of interleukin-6 production GO:0032715 ISO
    intracellular triglyceride homeostasis GO:0035356 ISO
    glucose homeostasis GO:0042593 IDA
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IDA
    negative regulation of gluconeogenesis GO:0045721 IDA
    negative regulation of gluconeogenesis GO:0045721 ISO
    negative regulation of gluconeogenesis GO:0045721 ISO
    negative regulation of inflammatory response GO:0050728 ISO
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IDA
    positive regulation of adiponectin secretion GO:0070165 IDA
    positive regulation of adiponectin secretion GO:0070165 ISO
    ERK1 and ERK2 cascade GO:0070371 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    negative regulation of monocyte chemotactic protein-1 production GO:0071638 ISO
    negative regulation of non-canonical NF-kappaB signal transduction GO:1901223 ISO
Subcellular Localization
    extracellular region GO:0005576 IDA
    collagen trimer GO:0005581 IEA
    extracellular space GO:0005615 IDA
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified C1qtnf3 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for C1qtnf3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which C1qtnf3 is involved
No pathways found





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