Gene description for Aldh6a1
Gene name aldehyde dehydrogenase 6 family, member A1
Gene symbol Aldh6a1
Other names/aliases Mmsdh
Species Rattus norvegicus
 Database cross references - Aldh6a1
ExoCarta ExoCarta_81708
Vesiclepedia VP_81708
Entrez Gene 81708
UniProt Q02253  
 Aldh6a1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Hepatocytes 19367702    
 Gene ontology annotations for Aldh6a1
Molecular Function
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 IBA
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 IDA
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 IEA
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 ISO
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 NAS
    thiolester hydrolase activity GO:0016790 IDA
    malonate-semialdehyde dehydrogenase (acetylating) activity GO:0018478 IEA
Biological Process
    thymine catabolic process GO:0006210 IBA
    thymine catabolic process GO:0006210 IDA
    thymine catabolic process GO:0006210 IEA
    thymine catabolic process GO:0006210 ISO
    valine metabolic process GO:0006573 IDA
    valine catabolic process GO:0006574 IBA
    valine catabolic process GO:0006574 IDA
    valine catabolic process GO:0006574 IEA
    valine catabolic process GO:0006574 ISO
    beta-alanine catabolic process GO:0019484 IDA
    thymine metabolic process GO:0019859 IDA
    brown fat cell differentiation GO:0050873 IEA
    brown fat cell differentiation GO:0050873 ISO
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
 Experiment description of studies that identified Aldh6a1 in sEVs
1
Experiment ID 225
MISEV standards
EM
Biophysical techniques
GAPDH|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Aldh6a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aldh6a1 is involved
PathwayEvidenceSource
Branched-chain amino acid catabolism IEA Reactome
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome





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