Gene description for Aldh6a1
Gene name aldehyde dehydrogenase 6 family, member A1
Gene symbol Aldh6a1
Other names/aliases Mmsdh
Species Rattus norvegicus
 Database cross references - Aldh6a1
ExoCarta ExoCarta_81708
Vesiclepedia VP_81708
Entrez Gene 81708
UniProt Q02253  
 Aldh6a1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Hepatocytes 19367702    
 Gene ontology annotations for Aldh6a1
Molecular Function
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 IBA
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 IDA
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 IEA
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 ISO
    methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO:0004491 NAS
    thiolester hydrolase activity GO:0016790 IDA
    malonate-semialdehyde dehydrogenase (acetylating) activity GO:0018478 IEA
Biological Process
    thymine catabolic process GO:0006210 IBA
    thymine catabolic process GO:0006210 IDA
    thymine catabolic process GO:0006210 IEA
    thymine catabolic process GO:0006210 ISO
    valine metabolic process GO:0006573 IDA
    valine catabolic process GO:0006574 IBA
    valine catabolic process GO:0006574 IDA
    valine catabolic process GO:0006574 IEA
    valine catabolic process GO:0006574 ISO
    beta-alanine catabolic process GO:0019484 IDA
    thymine metabolic process GO:0019859 IDA
    brown fat cell differentiation GO:0050873 IEA
    brown fat cell differentiation GO:0050873 ISO
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
 Experiment description of studies that identified Aldh6a1 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Aldh6a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aldh6a1 is involved
PathwayEvidenceSource
Branched-chain amino acid catabolism IEA Reactome
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome





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