Gene description for Abat
Gene name	4-aminobutyrate aminotransferase
Gene symbol	Abat
Other names/aliases	Gabat beta-AlaAT
Species	Rattus norvegicus
Database cross references - Abat
ExoCarta	ExoCarta_81632
Vesiclepedia	VP_81632
Entrez Gene	81632
UniProt	P50554
Abat identified in sEVs derived from the following tissue/cell type
Hepatocytes	19367702
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479

Gene ontology annotations for Abat

Molecular Function     transaminase activity GO:0008483 IEA     pyridoxal phosphate binding GO:0030170 IBA     pyridoxal phosphate binding GO:0030170 IEA     pyridoxal phosphate binding GO:0030170 ISO     pyridoxal phosphate binding GO:0030170 ISS     succinate-semialdehyde dehydrogenase binding GO:0032145 ISO     succinate-semialdehyde dehydrogenase binding GO:0032145 ISS     4-aminobutyrate:2-oxoglutarate transaminase activity GO:0034386 IDA     4-aminobutyrate:2-oxoglutarate transaminase activity GO:0034386 ISO     4-aminobutyrate:2-oxoglutarate transaminase activity GO:0034386 ISO     4-aminobutyrate:2-oxoglutarate transaminase activity GO:0034386 ISS     identical protein binding GO:0042802 ISO     identical protein binding GO:0042802 ISS     protein homodimerization activity GO:0042803 ISO     metal ion binding GO:0046872 IEA     (S)-3-amino-2-methylpropionate transaminase activity GO:0047298 IEA     iron-sulfur cluster binding GO:0051536 IEA Biological Process     response to hypoxia GO:0001666 IMP     copulation GO:0007620 IMP     locomotory behavior GO:0007626 IMP     response to xenobiotic stimulus GO:0009410 IDA     gamma-aminobutyric acid metabolic process GO:0009448 ISO     gamma-aminobutyric acid biosynthetic process GO:0009449 IMP     gamma-aminobutyric acid catabolic process GO:0009450 IBA     gamma-aminobutyric acid catabolic process GO:0009450 ISO     response to iron ion GO:0010039 IDA     negative regulation of gamma-aminobutyric acid secretion GO:0014053 IMP     cerebellum development GO:0021549 IEP     positive regulation of heat generation GO:0031652 IMP     positive regulation of insulin secretion GO:0032024 IMP     negative regulation of dopamine secretion GO:0033602 IMP     response to nicotine GO:0035094 IMP     exploration behavior GO:0035640 IMP     response to cocaine GO:0042220 IMP     response to ethanol GO:0045471 IDA     negative regulation of blood pressure GO:0045776 IMP     positive regulation of dopamine metabolic process GO:0045964 IMP     behavioral response to cocaine GO:0048148 ISO     nervous system process GO:0050877 ISS     positive regulation of uterine smooth muscle contraction GO:0070474 IMP     positive regulation of inhibitory postsynaptic potential GO:0097151 IMP     positive regulation of prolactin secretion GO:1902722 IMP     positive regulation of aspartate secretion GO:1904450 IMP Subcellular Localization     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 ISO     mitochondrion GO:0005739 ISS     mitochondrial matrix GO:0005759 IDA     4-aminobutyrate transaminase complex GO:0032144 ISO     4-aminobutyrate transaminase complex GO:0032144 ISS