Gene description for Itga7
Gene name integrin, alpha 7
Gene symbol Itga7
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Itga7
ExoCarta ExoCarta_81008
Entrez Gene 81008
UniProt Q63258  
 Itga7 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Itga7
Molecular Function
    cell adhesion molecule binding GO:0050839 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    protein heterodimerization activity GO:0046982 IMP
    integrin binding GO:0005178 IPI
    laminin binding GO:0043236 ISO
Biological Process
    skeletal muscle tissue development GO:0007519 IEP
    blood vessel morphogenesis GO:0048514 ISO
    integrin-mediated signaling pathway GO:0007229 IEA
    cell adhesion GO:0007155 ISO
    heterotypic cell-cell adhesion GO:0034113 ISO
    cell migration GO:0016477 ISO
    regulation of cell shape GO:0008360 IEA
    endodermal cell differentiation GO:0035987 ISO
Subcellular Localization
    integrin alpha7-beta1 complex GO:0034677 ISO
    cytoplasm GO:0005737 ISO
    neuromuscular junction GO:0031594 ISO
    cell surface GO:0009986 IDA
    muscle tendon junction GO:0005927 ISO
    integrin complex GO:0008305 IEA
    sarcolemma GO:0042383 ISO
 Experiment description of studies that identified Itga7 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Itga7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Itga7 is involved
PathwayEvidenceSource
ECM proteoglycans IEA Reactome
Laminin interactions IEA Reactome





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