Gene description for Trim23
Gene name tripartite motif-containing 23
Gene symbol Trim23
Other names/aliases 6330516O20Rik
AI450195
Arfd1
Species Mus musculus
 Database cross references - Trim23
ExoCarta ExoCarta_81003
Vesiclepedia VP_81003
Entrez Gene 81003
UniProt Q8BGX0  
 Trim23 identified in sEVs derived from the following tissue/cell type
Basophilic leukemia cells 20424270    
 Gene ontology annotations for Trim23
Molecular Function
    GTPase activity GO:0003924 ISO
    GTPase activity GO:0003924 ISS
    ubiquitin-protein transferase activity GO:0004842 ISO
    ubiquitin-protein transferase activity GO:0004842 ISS
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 ISO
    GTP binding GO:0005525 ISS
    zinc ion binding GO:0008270 IEA
    GDP binding GO:0019003 ISO
    GDP binding GO:0019003 ISS
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    ubiquitin protein ligase activity GO:0061630 IEA
    ubiquitin protein ligase activity GO:0061630 ISO
Biological Process
    intracellular protein transport GO:0006886 IBA
    positive regulation of autophagy GO:0010508 IEA
    positive regulation of autophagy GO:0010508 ISO
    vesicle-mediated transport GO:0016192 IBA
    protein ubiquitination GO:0016567 IEA
    protein ubiquitination GO:0016567 ISO
    protein ubiquitination GO:0016567 ISS
    positive regulation of protein modification process GO:0031401 ISO
Subcellular Localization
    Golgi membrane GO:0000139 ISO
    Golgi membrane GO:0000139 ISS
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    lysosomal membrane GO:0005765 IBA
    lysosomal membrane GO:0005765 ISO
    lysosomal membrane GO:0005765 ISS
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified Trim23 in sEVs
1
Experiment ID 89
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20424270    
Organism Rattus norvegicus
Experiment description Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.
Authors "Subra C, Grand D, Laulagnier K, Stella A, Lambeau G, Paillasse M, De Medina P, Monsarrat B, Perret B, Silvente-Poirot S, Poirot M, Record M."
Journal name JLR
Publication year 2010
Sample Basophilic leukemia cells
Sample name RBL-2H3
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Gas chromatography
Thin layer chromatography
Mass spectrometry [Qstar XL]
FACS
 Protein-protein interactions for Trim23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Trim23 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here