Gene description for Cyba
Gene name	cytochrome b-245, alpha polypeptide
Gene symbol	Cyba
Other names/aliases	p22-phox
Species	Rattus norvegicus
Database cross references - Cyba
ExoCarta	ExoCarta_79129
Vesiclepedia	VP_79129
Entrez Gene	79129
UniProt	Q62737
Cyba identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479
Reticulocytes	21828046

Gene ontology annotations for Cyba

Molecular Function     protein binding GO:0005515 IPI     electron transfer activity GO:0009055 IEA     electron transfer activity GO:0009055 ISO     superoxide-generating NAD(P)H oxidase activity GO:0016175 IEA     superoxide-generating NAD(P)H oxidase activity GO:0016175 IMP     superoxide-generating NAD(P)H oxidase activity GO:0016175 ISO     SH3 domain binding GO:0017124 IEA     SH3 domain binding GO:0017124 ISO     heme binding GO:0020037 IEA     metal ion binding GO:0046872 IEA     protein heterodimerization activity GO:0046982 IEA     protein heterodimerization activity GO:0046982 ISO Biological Process     response to hypoxia GO:0001666 IEP     positive regulation of endothelial cell proliferation GO:0001938 IMP     negative regulation of glomerular filtration by angiotensin GO:0003106 IMP     superoxide metabolic process GO:0006801 IDA     superoxide metabolic process GO:0006801 IMP     superoxide metabolic process GO:0006801 ISO     inflammatory response GO:0006954 IEA     inflammatory response GO:0006954 ISO     response to xenobiotic stimulus GO:0009410 IEP     response to activity GO:0014823 IEP     smooth muscle hypertrophy GO:0014895 IMP     cytochrome complex assembly GO:0017004 IEA     cytochrome complex assembly GO:0017004 ISO     positive regulation of cell growth GO:0030307 IMP     response to nutrient levels GO:0031667 IEP     positive regulation of interleukin-6 production GO:0032755 IEA     positive regulation of interleukin-6 production GO:0032755 ISO     positive regulation of tumor necrosis factor production GO:0032760 IEA     positive regulation of tumor necrosis factor production GO:0032760 ISO     positive regulation of superoxide anion generation GO:0032930 IMP     positive regulation of NAD(P)H oxidase activity GO:0033864 IMP     positive regulation of toll-like receptor 2 signaling pathway GO:0034137 IEA     positive regulation of toll-like receptor 2 signaling pathway GO:0034137 ISO     superoxide anion generation GO:0042554 IBA     superoxide anion generation GO:0042554 IEA     superoxide anion generation GO:0042554 IMP     superoxide anion generation GO:0042554 ISO     innate immune response GO:0045087 IEA     innate immune response GO:0045087 ISO     innate immune response GO:0045087 ISS     respiratory burst GO:0045730 IEA     respiratory burst GO:0045730 ISO     positive regulation of blood pressure GO:0045777 IMP     positive regulation of smooth muscle cell proliferation GO:0048661 IMP     hydrogen peroxide biosynthetic process GO:0050665 IMP     positive regulation of phagocytosis GO:0050766 IEA     positive regulation of phagocytosis GO:0050766 ISO     regulation of release of sequestered calcium ion into cytosol GO:0051279 IEA     regulation of release of sequestered calcium ion into cytosol GO:0051279 ISO     establishment of localization in cell GO:0051649 IEA     establishment of localization in cell GO:0051649 ISO     mucus secretion GO:0070254 IEA     mucus secretion GO:0070254 ISO     positive regulation of mucus secretion GO:0070257 IEA     positive regulation of mucus secretion GO:0070257 ISO     response to interleukin-1 GO:0070555 IEP     cellular response to amino acid stimulus GO:0071230 IEP     cellular response to mechanical stimulus GO:0071260 IEP     cellular response to glucose stimulus GO:0071333 IEP     cellular response to tumor necrosis factor GO:0071356 IEP     cellular response to organic cyclic compound GO:0071407 IEP     cellular response to gamma radiation GO:0071480 IEP     reactive oxygen species metabolic process GO:0072593 ISO     positive regulation of defense response to bacterium GO:1900426 IEA     positive regulation of defense response to bacterium GO:1900426 ISO     positive regulation of reactive oxygen species biosynthetic process GO:1903428 IEA     positive regulation of reactive oxygen species biosynthetic process GO:1903428 ISO     response to aldosterone GO:1904044 IEP     cellular response to angiotensin GO:1904385 IEP     cellular response to L-glutamine GO:1904845 IEP     positive regulation of oxygen metabolic process GO:2000376 ISO Subcellular Localization     stress fiber GO:0001725 IDA     cytoplasm GO:0005737 ISO     endosome GO:0005768 IEA     endosome GO:0005768 ISO     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     focal adhesion GO:0005925 IDA     apical plasma membrane GO:0016324 IDA     dendrite GO:0030425 IDA     NADPH oxidase complex GO:0043020 IBA     NADPH oxidase complex GO:0043020 IDA     NADPH oxidase complex GO:0043020 IEA     NADPH oxidase complex GO:0043020 IMP     NADPH oxidase complex GO:0043020 ISO     neuronal cell body GO:0043025 IDA     perinuclear endoplasmic reticulum GO:0097038 IDA