Gene description for Slc9a8
Gene name solute carrier family 9 (sodium/hydrogen exchanger), member 8
Gene symbol Slc9a8
Other names/aliases 1200006P13Rik
6430709P13Rik
AI182282
NHE-8
NHE8
Species Mus musculus
 Database cross references - Slc9a8
ExoCarta ExoCarta_77031
Vesiclepedia VP_77031
Entrez Gene 77031
UniProt Q8R4D1  
 Slc9a8 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Slc9a8
Molecular Function
    sodium:proton antiporter activity GO:0015385 IBA
    sodium:proton antiporter activity GO:0015385 ISO
    sodium:proton antiporter activity GO:0015385 ISS
    potassium:proton antiporter activity GO:0015386 IBA
    potassium:proton antiporter activity GO:0015386 IEA
    potassium:proton antiporter activity GO:0015386 ISO
Biological Process
    acrosome assembly GO:0001675 IMP
    sodium ion transmembrane transport GO:0035725 IEA
    sodium ion transmembrane transport GO:0035725 ISO
    sodium ion transmembrane transport GO:0035725 ISS
    regulation of intracellular pH GO:0051453 IBA
    regulation of intracellular pH GO:0051453 IDA
    regulation of intracellular pH GO:0051453 ISO
    potassium ion transmembrane transport GO:0071805 IBA
    potassium ion transmembrane transport GO:0071805 IEA
    proton transmembrane transport GO:1902600 IEA
    proton transmembrane transport GO:1902600 ISO
    proton transmembrane transport GO:1902600 ISS
    regulation of Golgi lumen acidification GO:1905526 IEA
    regulation of Golgi lumen acidification GO:1905526 ISO
Subcellular Localization
    Golgi membrane GO:0000139 ISO
    Golgi membrane GO:0000139 ISS
    acrosomal vesicle GO:0001669 IDA
    apical plasma membrane GO:0016324 IDA
    apical plasma membrane GO:0016324 ISO
    multivesicular body membrane GO:0032585 IEA
    multivesicular body membrane GO:0032585 ISO
    trans-Golgi network membrane GO:0032588 IEA
    trans-Golgi network membrane GO:0032588 ISO
 Experiment description of studies that identified Slc9a8 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Slc9a8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml



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