Gene description for Rftn1
Gene name raftlin lipid raft linker 1
Gene symbol Rftn1
Other names/aliases 2310015N21Rik
AI853526
Species Mus musculus
 Database cross references - Rftn1
ExoCarta ExoCarta_76438
Vesiclepedia VP_76438
Entrez Gene 76438
UniProt Q6A0D4  
 Rftn1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Rftn1
Molecular Function
    double-stranded RNA binding GO:0003725 ISO
Biological Process
    membrane raft assembly GO:0001765 IEA
    membrane raft assembly GO:0001765 ISO
    T cell antigen processing and presentation GO:0002457 IMP
    protein transport into membrane raft GO:0032596 IMP
    positive regulation of interleukin-17 production GO:0032740 IMP
    dsRNA transport GO:0033227 ISO
    toll-like receptor 3 signaling pathway GO:0034138 ISO
    positive regulation of growth rate GO:0040010 IEA
    positive regulation of growth rate GO:0040010 ISO
    response to exogenous dsRNA GO:0043330 ISO
    T cell receptor signaling pathway GO:0050852 IMP
    B cell receptor signaling pathway GO:0050853 IEA
    B cell receptor signaling pathway GO:0050853 ISO
    protein localization to membrane raft GO:1903044 IMP
Subcellular Localization
    cytoplasm GO:0005737 ISO
    endosome GO:0005768 ISO
    early endosome GO:0005769 IEA
    plasma membrane GO:0005886 ISO
    protein-containing complex GO:0032991 ISO
    membrane raft GO:0045121 ISO
 Experiment description of studies that identified Rftn1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rftn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rftn1 is involved
No pathways found





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