Gene description for Rab2b
Gene name RAB2B, member RAS oncogene family
Gene symbol Rab2b
Other names/aliases 1500012D09Rik
4930528G15Rik
A230002G14
D530043M21Rik
Species Mus musculus
 Database cross references - Rab2b
ExoCarta ExoCarta_76338
Vesiclepedia VP_76338
Entrez Gene 76338
UniProt P59279  
 Rab2b identified in sEVs derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Rab2b
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IEA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IEA
Biological Process
    Golgi organization GO:0007030 ISO
    Golgi organization GO:0007030 ISS
    protein transport GO:0015031 IEA
    vesicle-mediated transport GO:0016192 IBA
    vesicle-mediated transport GO:0016192 IEA
    macroautophagy GO:0016236 IMP
    positive regulation of type I interferon production GO:0032481 IDA
    innate immune response GO:0045087 IDA
    positive regulation of exocytosis GO:0045921 IBA
    positive regulation of exocytosis GO:0045921 IEA
    positive regulation of exocytosis GO:0045921 ISO
    defense response to virus GO:0051607 IDA
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    Golgi membrane GO:0000139 IEA
    autophagosome membrane GO:0000421 IDA
    acrosomal vesicle GO:0001669 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 ISO
    Golgi apparatus GO:0005794 ISS
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified Rab2b in sEVs
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Rab2b
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SMAD4  
Affinity Capture-Luminescence Homo sapiens
2 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Rab2b is involved
PathwayEvidenceSource
Metabolism of proteins IEA Reactome
Post-translational protein modification IEA Reactome
RAB geranylgeranylation IEA Reactome





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