Gene description for Fam63a
Gene name family with sequence similarity 63, member A
Gene symbol Fam63a
Other names/aliases 1810005H09Rik
4930504E06Rik
AA562754
AA960384
AW561904
cI-40
mKIAA1390
ni
Species Mus musculus
 Database cross references - Fam63a
ExoCarta ExoCarta_75007
Vesiclepedia VP_75007
Entrez Gene 75007
UniProt Q76LS9  
 Fam63a identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Fam63a
Molecular Function
    cysteine-type deubiquitinase activity GO:0004843 IEA
    cysteine-type carboxypeptidase activity GO:0016807 IBA
    cysteine-type carboxypeptidase activity GO:0016807 IEA
    cysteine-type carboxypeptidase activity GO:0016807 ISO
    K48-linked polyubiquitin modification-dependent protein binding GO:0036435 ISO
    K48-linked polyubiquitin modification-dependent protein binding GO:0036435 ISS
    K48-linked deubiquitinase activity GO:1990380 IBA
    K48-linked deubiquitinase activity GO:1990380 IEA
    K48-linked deubiquitinase activity GO:1990380 ISO
Biological Process
    proteolysis GO:0006508 IEA
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    nuclear body GO:0016604 IEA
    nuclear body GO:0016604 ISO
 Experiment description of studies that identified Fam63a in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Fam63a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fam63a is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here