Gene description for Lrrc15
Gene name leucine rich repeat containing 15
Gene symbol Lrrc15
Other names/aliases 5430427N11Rik
LIB
Species Mus musculus
 Database cross references - Lrrc15
ExoCarta ExoCarta_74488
Vesiclepedia VP_74488
Entrez Gene 74488
UniProt Q80X72  
 Lrrc15 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Lrrc15
Molecular Function
    fibronectin binding GO:0001968 IEA
    fibronectin binding GO:0001968 ISO
    collagen binding GO:0005518 IEA
    collagen binding GO:0005518 ISO
    laminin binding GO:0043236 IEA
    laminin binding GO:0043236 ISO
    protein sequestering activity GO:0140311 IEA
    protein sequestering activity GO:0140311 ISO
Biological Process
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    negative regulation of viral entry into host cell GO:0046597 IEA
    negative regulation of viral entry into host cell GO:0046597 ISO
    receptor-mediated virion attachment to host cell GO:0046813 IEA
    receptor-mediated virion attachment to host cell GO:0046813 ISO
    negative regulation of protein localization to plasma membrane GO:1903077 IEA
    negative regulation of protein localization to plasma membrane GO:1903077 ISO
Subcellular Localization
    extracellular space GO:0005615 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    cell surface GO:0009986 ISO
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
    extracellular matrix GO:0031012 IBA
    collagen-containing extracellular matrix GO:0062023 IEA
    collagen-containing extracellular matrix GO:0062023 ISO
 Experiment description of studies that identified Lrrc15 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Lrrc15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Lrrc15 is involved
No pathways found





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