Gene description for Sash3
Gene name SAM and SH3 domain containing 3
Gene symbol Sash3
Other names/aliases 1200013B08Rik
AW413946
SLY1
Species Mus musculus
 Database cross references - Sash3
ExoCarta ExoCarta_74131
Vesiclepedia VP_74131
Entrez Gene 74131
UniProt Q8K352  
 Sash3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Sash3
Biological Process
    B cell homeostasis GO:0001782 IMP
    T cell cytokine production GO:0002369 IMP
    positive regulation of immunoglobulin production GO:0002639 IBA
    positive regulation of immunoglobulin production GO:0002639 IMP
    positive regulation of T cell cytokine production GO:0002726 IMP
    positive regulation of adaptive immune response GO:0002821 IBA
    positive regulation of adaptive immune response GO:0002821 IMP
    positive regulation of B cell proliferation GO:0030890 IBA
    positive regulation of B cell proliferation GO:0030890 IMP
    type II interferon production GO:0032609 IMP
    interleukin-10 production GO:0032613 IMP
    interleukin-2 production GO:0032623 IMP
    interleukin-4 production GO:0032633 IMP
    tumor necrosis factor production GO:0032640 IMP
    positive regulation of type II interferon production GO:0032729 IMP
    positive regulation of interleukin-10 production GO:0032733 IMP
    positive regulation of interleukin-2 production GO:0032743 IMP
    positive regulation of interleukin-4 production GO:0032753 IMP
    positive regulation of tumor necrosis factor production GO:0032760 IMP
    T cell proliferation GO:0042098 IMP
    B cell proliferation GO:0042100 IMP
    positive regulation of T cell proliferation GO:0042102 IMP
    CD4-positive, alpha-beta T cell differentiation GO:0043367 IMP
    positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0043372 IMP
    positive regulation of organ growth GO:0046622 IMP
    homeostasis of number of cells within a tissue GO:0048873 IMP
    positive regulation of lymphocyte activation GO:0051251 IMP
    regulation of intracellular signal transduction GO:1902531 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified Sash3 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Sash3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Foxp3  
Affinity Capture-MS Mus musculus
2 Usp7  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Sash3 is involved
No pathways found





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